血液透析患者颈动脉内膜-中膜厚度及相关生化和临床因素。

IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY
Iranian journal of kidney diseases Pub Date : 2023-01-01
Azita Zafar Mohtashami, Babak Hadian, Mohammad Heidarian, Parisa Khalili
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引用次数: 0

摘要

导读:心血管并发症是慢性肾脏疾病中最常见的死亡原因,这是由一般和尿毒症危险因素引起的。近年来,医学文献报道颈动脉内膜-中膜厚度是预测心血管疾病的指标之一。方法:对128例血液透析患者进行横断面分析研究。研究人员通过查阅病历、对患者进行访谈、对患者血清和颈动脉多普勒超声进行化学分析以及提供相关问卷来收集数据。我们进行了描述性统计、双变量相关和一般线性模型(GLM)分析。假设检验的显著性水平为0.05。结果:男性73例(57%),女性55例(43%)。年龄的平均值和标准差为58.66±15.54岁。近42%的患者患有糖尿病,95.3%的患者患有高血压,28.1%的患者有心血管病史。在双变量分析中,年龄、血清白蛋白、血清镁、高血压和心血管疾病史与颈动脉内膜-中膜厚度(CIMT)有统计学意义的关系。在GLM中,我们观察到CIMT、年龄和镁之间有统计学意义的关系。结论:相当比例的血液透析患者CIMT升高。年龄和血清镁浓度与CIMT有显著的统计学相关性。我们建议进行更精确的长期纵向随访研究,以调查生化危险因素与CIMT之间的关系。因此,有必要进行多变量分析,以评估自变量的同时效应,并管理混杂因素的影响。我们还建议制定一个实用的指南,定期测定血液透析患者的CIMT,以实施方便的预防或治疗措施。DOI: 10.52547 / ijkd.7303。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carotid Intima-media Thickness in Hemodialysis Patients and Related Biochemical and Clinical Factors.

Introduction: Cardiovascular complications are the most frequent cause of death in chronic kidney disease that happens due to both general and uremic risk factors. Recently, the medical literature has declared the carotid artery intima-media thickness to be an indicator for predicting cardiovascular diseases.

Methods: This paper is an attempt to introduce an analytical cross-sectional study of 128 hemodialysis patients. The researchers collected the data by reviewing medical records, interviewing the patients, chemical analysis of the patient's serum and carotid artery Doppler ultrasound, and providing the relevant questionnaire. We performed descriptive statistics, bivariate correlation, and general linear model (GLM) analysis. And, the significance level of hypothesis tests was .05.

Results: Seventy-three patients (57%) were male, and 55 (43%) were female. The mean and standard deviation of the age was 58.66 ± 15.54 years. Nearly 42% of patients affected by diabetes, 95.3% were hypertensive and 28.1% had a history of cardiovascular disease. In the bivariate analysis, age, serum albumin, serum magnesium, hypertension, and history of cardiovascular disease showed a statistically significant relationship with carotid intima-media thickness (CIMT). In GLM, we observed a statistically significant relationship between CIMT, age and magnesium.

Conclusion: Increased CIMT is observed in a considerable percentage of hemodialysis patients. Age and serum magnesium concentration demonstrate a statistically significant association with CIMT. We recommend more precise long-term longitudinal follow-up studies to investigate the relationship between biochemical risk factors and CIMT. Therefore, multivariate analysis is necessary to assess the simultaneous effects of independent variables and manage influences of confounding factors. We also recommend developing a practical guideline for periodic determination of CIMT in hemodialysis patients to implement convenient preventive or therapeutic measures.  DOI: 10.52547/ijkd.7303.

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来源期刊
Iranian journal of kidney diseases
Iranian journal of kidney diseases UROLOGY & NEPHROLOGY-
CiteScore
2.50
自引率
0.00%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.
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