Fang Liu, Haipeng Liu, M. Sollogoub, Yongming Zhang
{"title":"鞘糖脂GM3研究进展","authors":"Fang Liu, Haipeng Liu, M. Sollogoub, Yongming Zhang","doi":"10.1039/9781788013864-00230","DOIUrl":null,"url":null,"abstract":"Ganglioside GM3 has a strong impact on the occurrence and development of human cancer. GM3 is not only overexpressed in several types of cancer but also inhibits tumor cell growth through anti-angiogenesis or motility. In particular, the effect of GM3 on EGFR tyrosine kinase signaling is essential for cancer. GM3 analogs showed better tumor-suppressive activity than GM3. GM3 is also associated with diabetes, regulating the content of GM3 can regulate the mechanism of insulin signaling and improve insulin resistance, which could provide powerful help for the development and application of GM3 and its analogs in the prevention and treatment of type II diabetes. GM3, especially its specifically modified analogs, would become the most promising target molecule for cancer and diabetes treatment.","PeriodicalId":89334,"journal":{"name":"Carbohydrate chemistry","volume":"44 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent advances on glycosphingolipid GM3\",\"authors\":\"Fang Liu, Haipeng Liu, M. Sollogoub, Yongming Zhang\",\"doi\":\"10.1039/9781788013864-00230\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ganglioside GM3 has a strong impact on the occurrence and development of human cancer. GM3 is not only overexpressed in several types of cancer but also inhibits tumor cell growth through anti-angiogenesis or motility. In particular, the effect of GM3 on EGFR tyrosine kinase signaling is essential for cancer. GM3 analogs showed better tumor-suppressive activity than GM3. GM3 is also associated with diabetes, regulating the content of GM3 can regulate the mechanism of insulin signaling and improve insulin resistance, which could provide powerful help for the development and application of GM3 and its analogs in the prevention and treatment of type II diabetes. GM3, especially its specifically modified analogs, would become the most promising target molecule for cancer and diabetes treatment.\",\"PeriodicalId\":89334,\"journal\":{\"name\":\"Carbohydrate chemistry\",\"volume\":\"44 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Carbohydrate chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/9781788013864-00230\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbohydrate chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/9781788013864-00230","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Ganglioside GM3 has a strong impact on the occurrence and development of human cancer. GM3 is not only overexpressed in several types of cancer but also inhibits tumor cell growth through anti-angiogenesis or motility. In particular, the effect of GM3 on EGFR tyrosine kinase signaling is essential for cancer. GM3 analogs showed better tumor-suppressive activity than GM3. GM3 is also associated with diabetes, regulating the content of GM3 can regulate the mechanism of insulin signaling and improve insulin resistance, which could provide powerful help for the development and application of GM3 and its analogs in the prevention and treatment of type II diabetes. GM3, especially its specifically modified analogs, would become the most promising target molecule for cancer and diabetes treatment.
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