{"title":"ICU医院获得性感染肺炎克雷伯菌质粒介导的喹诺酮类耐药基因(Qnr A和S","authors":"Ghada Mashaly, H. Mohammed, H. Nagib","doi":"10.21608/ejmm.2022.265573","DOIUrl":null,"url":null,"abstract":"Background: Klebsiella pneumoniae causes any types of hospital-acquired infections (HAIs). Resistance to quinolone antibiotics increased rapidly in K. pneumoniae. Objectives: This study was designed to investigate the prevalence of quinolone resistance, detection of plasmid mediated (qnrA and qnrS) genes in K. pneumoniae causing hospital-acquired infections (HAIs) in ICUs of Mansoura Emergency Hospital. Additionally, determination of risk factors for quinolone resistance. Methodology: K. pneumoniae isolates were collected from different samples of patients admitted to Mansoura Emergency Hospital and presented with different infections. K. pneumoniae isolation and identification was performed by biochemical reactions. K. pneumoniae quinolone susceptibility was identified by disc diffusion method. The qnrA and qnrS were detected by PCR. Results: A total of 65 K. pneumoniae isolates were recovered in the studied ICUs patients samples. The highest resistance of K. pneumoniae isolates was to ciprofloxacin and ceftriaxone (80% and 70%, respectively). The qnrS gene was detected in 28 cases, and qnrA was detected in 2 cases. Regarding risk factors","PeriodicalId":22549,"journal":{"name":"The Egyptian Journal of Medical Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Plasmid Mediated Quinolone Resistance Genes (Qnr A and S) in Klebsiella pneumoniae Isolated from ICU Hospital Acquired Infection\",\"authors\":\"Ghada Mashaly, H. Mohammed, H. Nagib\",\"doi\":\"10.21608/ejmm.2022.265573\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Klebsiella pneumoniae causes any types of hospital-acquired infections (HAIs). Resistance to quinolone antibiotics increased rapidly in K. pneumoniae. Objectives: This study was designed to investigate the prevalence of quinolone resistance, detection of plasmid mediated (qnrA and qnrS) genes in K. pneumoniae causing hospital-acquired infections (HAIs) in ICUs of Mansoura Emergency Hospital. Additionally, determination of risk factors for quinolone resistance. Methodology: K. pneumoniae isolates were collected from different samples of patients admitted to Mansoura Emergency Hospital and presented with different infections. K. pneumoniae isolation and identification was performed by biochemical reactions. K. pneumoniae quinolone susceptibility was identified by disc diffusion method. The qnrA and qnrS were detected by PCR. Results: A total of 65 K. pneumoniae isolates were recovered in the studied ICUs patients samples. The highest resistance of K. pneumoniae isolates was to ciprofloxacin and ceftriaxone (80% and 70%, respectively). The qnrS gene was detected in 28 cases, and qnrA was detected in 2 cases. Regarding risk factors\",\"PeriodicalId\":22549,\"journal\":{\"name\":\"The Egyptian Journal of Medical Microbiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Egyptian Journal of Medical Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/ejmm.2022.265573\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Egyptian Journal of Medical Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/ejmm.2022.265573","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Plasmid Mediated Quinolone Resistance Genes (Qnr A and S) in Klebsiella pneumoniae Isolated from ICU Hospital Acquired Infection
Background: Klebsiella pneumoniae causes any types of hospital-acquired infections (HAIs). Resistance to quinolone antibiotics increased rapidly in K. pneumoniae. Objectives: This study was designed to investigate the prevalence of quinolone resistance, detection of plasmid mediated (qnrA and qnrS) genes in K. pneumoniae causing hospital-acquired infections (HAIs) in ICUs of Mansoura Emergency Hospital. Additionally, determination of risk factors for quinolone resistance. Methodology: K. pneumoniae isolates were collected from different samples of patients admitted to Mansoura Emergency Hospital and presented with different infections. K. pneumoniae isolation and identification was performed by biochemical reactions. K. pneumoniae quinolone susceptibility was identified by disc diffusion method. The qnrA and qnrS were detected by PCR. Results: A total of 65 K. pneumoniae isolates were recovered in the studied ICUs patients samples. The highest resistance of K. pneumoniae isolates was to ciprofloxacin and ceftriaxone (80% and 70%, respectively). The qnrS gene was detected in 28 cases, and qnrA was detected in 2 cases. Regarding risk factors
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