达芬唑胺A和B的合成研究

IF 1.4 4区化学 Q3 CHEMISTRY, ORGANIC

Synlett Pub Date : 2023-02-26 DOI:10.1055/s-0041-1738436

Chenguang Dou, Ming-Hsiu Yang

引用次数: 1

摘要

本文报道了水蚤属生物碱基团中具有罕见的azaadamantane核心结构的dapnezomines A和B的合成研究。以(R)-胡椒酮为原料，经9步合成了具有两个连续季碳中心的三环碳骨架。分子内的Tsuji-Trost反应被用作骨架组装的关键反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthetic Studies Toward Daphnezomines A and B

Synthetic studies toward daphnezomines A and B, members of Daphniphyllum alkaloid group with a rare azaadamantane core structure, are reported. The tricyclic carbon skeleton with two contiguous quaternary carbon centers was synthesized in nine steps from (R)-piperitone. An intramolecular Tsuji–Trost reaction was used as a key reaction for the assembly of the skeleton.

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.