中国脑卒中后抑郁与病变部位的关系:一项系统回顾和荟萃分析。

EC psychology and psychiatry Pub Date : 2023-03-01
Xinqun Luo, Wenhua Fang, Jiawu Ji, Yong Zhang, Rolando Garcia-Milian, Zhiren Wang, Yunlong Tan, Shibin Wang, Xiaoping Wang, Xiaoyun Guo, Xingguang Luo
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引用次数: 0

摘要

背景:卒中后抑郁(PSD)是卒中后可能出现的一种心理健康状况,具有较高的死亡风险和负面结果。然而,有限的研究探讨了PSD发病率与中国患者脑位置的关系。本研究旨在通过研究PSD的发生与脑损伤部位以及患者所经历的中风类型之间的联系来填补这一空白。方法:系统检索数据库,收集2015年1月1日至2021年5月31日期间发表的脑卒中后抑郁文献。随后,我们使用RevMan进行meta分析,分别分析不同脑区和脑卒中类型与PSD发病率的关系。结果:我们分析了7项研究,共1604名参与者。我们的研究结果表明,当卒中发生在左半球时,PSD的发病率高于右半球(RevMan: Z = 8.93, P)。结论:我们的研究结果显示,PSD发生在左半球的可能性更高,特别是在大脑皮层和大脑前部。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of lesion location with post-stroke depression in China: a systematic review and meta-analysis.

Background: Post-stroke depression (PSD) is a mental health condition that can develop after a stroke, with a higher risk of death and negative outcomes. However, limited research has explored how PSD incidence relates to brain locations in Chinese patients. This study aims to fill this gap by examining the link between PSD occurrence and brain lesion location, as well as the type of stroke experienced by the patient.

Methods: We conducted a systematic search in databases to gather post-stroke depression literature published between January 1, 2015 and May 31, 2021. Following this, we performed a meta-analysis using RevMan to analyze the incidence of PSD associated with different brain regions and types of stroke separately.

Results: We analyzed seven studies, with a total of 1604 participants. Our findings indicated that the incidence of PSD was higher when the stroke occurred in the left hemisphere compared to the right hemisphere (RevMan: Z = 8.93, P <0.001, OR = 2.69, 95% CI: 2.16-3.34, fixed model); PSD was more common when the stroke affected the cerebral cortex rather than the subcerebral cortex (RevMan: Z = 3.96, P <0.001, OR = 2.00, 95% CI: 1.42-2.81) and when it affected the anterior cortex compared to the posterior cortex (RevMan: Z = 3.85, P <0.001, OR = 1.89, 95% CI: 1.37-2.62). However, we did not find a significant difference in the occurrence of PSD between ischemic and hemorrhagic strokes (RevMan: Z = 0.62, P = 0.53, OR = 0.02, 95% CI: -0.05-0.09).

Conclusions: Our findings revealed a higher likelihood of PSD in the left hemisphere, specifically in the cerebral cortex and anterior region.

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