{"title":"2型糖尿病多用途患者内皮素水平及其与尿酸的相关性","authors":"Z. Ismail, Z. H. Jawad, Ali Jasim Hammood","doi":"10.23851/mjs.v31i3.849","DOIUrl":null,"url":null,"abstract":"This research aims to find the direct linkage among the Uric acid rates with Endothelin (ET-1), which is considered the indication of endothelial dysfunction or endothelial damage in patients with T2-DM. This study, included 96 patients with T2-DM and 96 controls, the mean age ranged (56.73 ± 9.14), (56.42 ± 8.74) respectively. Results showed a highly significant increase in Endothelin (ET-1) levels, uric acid, urea, and systolic blood pressure (SBP) was observed as compared with the control group, while Diastolic blood pressure (DBP) and body mass (BMI) were not substantially increased. Additionally, a significant positive correlation was found between ET-1 with uric acid, urea, SBP, DBP in patients with T2-DM (p < 0.05). Finally, elevated uric acid levels in older people who have chronic blood pressure are one of the factors influencing the increased release of ET-1, thus the development of cardiovascular disease.","PeriodicalId":7515,"journal":{"name":"Al-Mustansiriyah Journal of Sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Endothelin Level and Its Correlation with Uric Acid in Type 2 Diabetic Multiuse Patients\",\"authors\":\"Z. Ismail, Z. H. Jawad, Ali Jasim Hammood\",\"doi\":\"10.23851/mjs.v31i3.849\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This research aims to find the direct linkage among the Uric acid rates with Endothelin (ET-1), which is considered the indication of endothelial dysfunction or endothelial damage in patients with T2-DM. This study, included 96 patients with T2-DM and 96 controls, the mean age ranged (56.73 ± 9.14), (56.42 ± 8.74) respectively. Results showed a highly significant increase in Endothelin (ET-1) levels, uric acid, urea, and systolic blood pressure (SBP) was observed as compared with the control group, while Diastolic blood pressure (DBP) and body mass (BMI) were not substantially increased. Additionally, a significant positive correlation was found between ET-1 with uric acid, urea, SBP, DBP in patients with T2-DM (p < 0.05). Finally, elevated uric acid levels in older people who have chronic blood pressure are one of the factors influencing the increased release of ET-1, thus the development of cardiovascular disease.\",\"PeriodicalId\":7515,\"journal\":{\"name\":\"Al-Mustansiriyah Journal of Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Al-Mustansiriyah Journal of Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23851/mjs.v31i3.849\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Al-Mustansiriyah Journal of Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23851/mjs.v31i3.849","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Endothelin Level and Its Correlation with Uric Acid in Type 2 Diabetic Multiuse Patients
This research aims to find the direct linkage among the Uric acid rates with Endothelin (ET-1), which is considered the indication of endothelial dysfunction or endothelial damage in patients with T2-DM. This study, included 96 patients with T2-DM and 96 controls, the mean age ranged (56.73 ± 9.14), (56.42 ± 8.74) respectively. Results showed a highly significant increase in Endothelin (ET-1) levels, uric acid, urea, and systolic blood pressure (SBP) was observed as compared with the control group, while Diastolic blood pressure (DBP) and body mass (BMI) were not substantially increased. Additionally, a significant positive correlation was found between ET-1 with uric acid, urea, SBP, DBP in patients with T2-DM (p < 0.05). Finally, elevated uric acid levels in older people who have chronic blood pressure are one of the factors influencing the increased release of ET-1, thus the development of cardiovascular disease.
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