胰腺癌和慢性胰腺炎的增殖活性和DNA倍体的意义。

H Loertzer, R Hinze, J Knolle, F W Rath, A Schmassmann
{"title":"胰腺癌和慢性胰腺炎的增殖活性和DNA倍体的意义。","authors":"H Loertzer,&nbsp;R Hinze,&nbsp;J Knolle,&nbsp;F W Rath,&nbsp;A Schmassmann","doi":"10.1007/BF02781734","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Precise preoperative assessment of diagnosis and prognosis in patients with pancreatic tumors would facilitate improvement of treatment strategies. In this context, we evaluated the significance of the proliferative index and of static DNA cytophotometry in the diagnosis and prognosis of pancreatic tumors.</p><p><strong>Methods: </strong>Consecutive surgical specimens from 26 patients with ductal pancreatic cancers and eight patients with chronic pancreatitis were investigated by: 1. Staging; 2. Conventional histological and cytological grading; 3. MIB-1 (Ki-67 labeling) proliferating index; and 4. Static DNA cytophotometry.</p><p><strong>Results: </strong>All patients with chronic pancreatitis had a normal MIB-1 labeling index and a euploid DNA content. In contrast, patients with pancreatic cancers rarely had a normal labeling index (1 of 26 patients) or a euploid DNA content (6 of 26 patients). Staging significantly correlated with survival time. However, it did not correlate with cytological criteria. Cytological criteria, such as conventional grading, MIB-1 proliferating index, and DNA ploidy, were not significantly correlated with survival time. Conventional grading was significantly correlated (p < 0.02) with proliferating index, but not with DNA ploidy.</p><p><strong>Conclusion: </strong>Proliferating index and DNA ploidy are relevant cytological markers that can help to discriminate between chronic pancreatitis and pancreatic cancer. The prognostic significance of these markers in pancreatic cancer patients, however, seems to be less relevant than tumor stage and of limited relevance for the individual cancer patient.</p>","PeriodicalId":73464,"journal":{"name":"International journal of pancreatology : official journal of the International Association of Pancreatology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02781734","citationCount":"3","resultStr":"{\"title\":\"Significance of proliferative activity and DNA ploidy in pancreatic cancer and chronic pancreatitis.\",\"authors\":\"H Loertzer,&nbsp;R Hinze,&nbsp;J Knolle,&nbsp;F W Rath,&nbsp;A Schmassmann\",\"doi\":\"10.1007/BF02781734\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Precise preoperative assessment of diagnosis and prognosis in patients with pancreatic tumors would facilitate improvement of treatment strategies. In this context, we evaluated the significance of the proliferative index and of static DNA cytophotometry in the diagnosis and prognosis of pancreatic tumors.</p><p><strong>Methods: </strong>Consecutive surgical specimens from 26 patients with ductal pancreatic cancers and eight patients with chronic pancreatitis were investigated by: 1. Staging; 2. Conventional histological and cytological grading; 3. MIB-1 (Ki-67 labeling) proliferating index; and 4. Static DNA cytophotometry.</p><p><strong>Results: </strong>All patients with chronic pancreatitis had a normal MIB-1 labeling index and a euploid DNA content. In contrast, patients with pancreatic cancers rarely had a normal labeling index (1 of 26 patients) or a euploid DNA content (6 of 26 patients). Staging significantly correlated with survival time. However, it did not correlate with cytological criteria. Cytological criteria, such as conventional grading, MIB-1 proliferating index, and DNA ploidy, were not significantly correlated with survival time. Conventional grading was significantly correlated (p < 0.02) with proliferating index, but not with DNA ploidy.</p><p><strong>Conclusion: </strong>Proliferating index and DNA ploidy are relevant cytological markers that can help to discriminate between chronic pancreatitis and pancreatic cancer. The prognostic significance of these markers in pancreatic cancer patients, however, seems to be less relevant than tumor stage and of limited relevance for the individual cancer patient.</p>\",\"PeriodicalId\":73464,\"journal\":{\"name\":\"International journal of pancreatology : official journal of the International Association of Pancreatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF02781734\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of pancreatology : official journal of the International Association of Pancreatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/BF02781734\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of pancreatology : official journal of the International Association of Pancreatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF02781734","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

摘要

背景:对胰腺肿瘤患者进行准确的术前诊断和预后评估有助于改善治疗策略。在此背景下,我们评估了增殖指数和静态DNA细胞光度法在胰腺肿瘤的诊断和预后中的意义。方法:对26例导管性胰腺癌患者和8例慢性胰腺炎患者的连续手术标本进行回顾性分析。分期;2. 常规组织学和细胞学分级;3.mb -1 (Ki-67标记)增殖指数;和4。静态DNA细胞光度法。结果:所有慢性胰腺炎患者的mb -1标记指数和整倍体DNA含量均正常。相比之下,胰腺癌患者很少有正常的标记指数(26例中有1例)或整倍体DNA含量(26例中有6例)。分期与生存时间显著相关。然而,它与细胞学标准无关。细胞学标准,如常规分级、mb -1增殖指数和DNA倍性,与生存时间无显著相关。常规分级与增殖指数显著相关(p < 0.02),与DNA倍性无显著相关性。结论:增殖指数和DNA倍体是鉴别慢性胰腺炎和胰腺癌的细胞学指标。然而,这些标志物在胰腺癌患者中的预后意义似乎与肿瘤分期的相关性较小,并且与个体癌症患者的相关性有限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Significance of proliferative activity and DNA ploidy in pancreatic cancer and chronic pancreatitis.

Background: Precise preoperative assessment of diagnosis and prognosis in patients with pancreatic tumors would facilitate improvement of treatment strategies. In this context, we evaluated the significance of the proliferative index and of static DNA cytophotometry in the diagnosis and prognosis of pancreatic tumors.

Methods: Consecutive surgical specimens from 26 patients with ductal pancreatic cancers and eight patients with chronic pancreatitis were investigated by: 1. Staging; 2. Conventional histological and cytological grading; 3. MIB-1 (Ki-67 labeling) proliferating index; and 4. Static DNA cytophotometry.

Results: All patients with chronic pancreatitis had a normal MIB-1 labeling index and a euploid DNA content. In contrast, patients with pancreatic cancers rarely had a normal labeling index (1 of 26 patients) or a euploid DNA content (6 of 26 patients). Staging significantly correlated with survival time. However, it did not correlate with cytological criteria. Cytological criteria, such as conventional grading, MIB-1 proliferating index, and DNA ploidy, were not significantly correlated with survival time. Conventional grading was significantly correlated (p < 0.02) with proliferating index, but not with DNA ploidy.

Conclusion: Proliferating index and DNA ploidy are relevant cytological markers that can help to discriminate between chronic pancreatitis and pancreatic cancer. The prognostic significance of these markers in pancreatic cancer patients, however, seems to be less relevant than tumor stage and of limited relevance for the individual cancer patient.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信