COVID-19患者严重并发症与血型的相关性分析T细胞凝集在促进血栓形成倾向中的可能作用

IF 0.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
G. Dobie, Sarah Abutalib, Wafa Sadifi, Mada Jahfali, B. Alghamdi, Asmaa Khormi, Taibah Alharbi, Munyah Zaqan, Zahra M Baalous, A. Hakami, M. Nahari, Abdullah A Mobarki, M. Saboor, Mohammad S Akhter, A. Hamadi, D. Jackson, Hassan A. Hamali
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引用次数: 1

摘要

由严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)引起的冠状病毒病-19 (COVID-19)仍在对人类造成有害影响。已确定感染COVID-19与ABO血型之间存在关联。然而,决定COVID-19严重程度的因素尚未完全了解。因此,本研究旨在探讨ABO血型是否与COVID-19并发症的严重程度有关。材料与方法从沙特阿拉伯Baish综合医院招募重症监护病房收治的COVID-19患者86例和匹配的健康对照80例。报告ABO血型、全血细胞计数(CBC)、CBC衍生炎症标志物、凝血谱、d -二聚体和抗t抗原。结果我们的数据显示,O型血和B型血的患者比A型血和AB型血的患者对COVID-19严重并发症的保护作用更强,这可能部分归因于A型血的个体比非A型血的个体存在抗t。抗t可能在驱动血栓形成倾向的机制中起作用,因为它也与d -二聚体水平升高相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The correlation between severe complications and blood group types in COVID-19 patients; with possible role of T polyagglutination in promoting thrombotic tendencies
Introduction Coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still posing detrimental effects on people. An association between contracting COVID-19 and the ABO blood group type has been determined. However, factors that determine the severity of COVID-19 are not yet fully understood. Thus, the current study aimed to investigate whether the ABO blood group type has a role in the severity of complications due to COVID-19. Materials and methods Eighty-Six ICU-admitted COVID-19 patients and 80 matched-healthy controls were recruited in the study from Baish general hospital, Saudi Arabia. ABO blood grouping, complete blood count (CBC), CBC-derived inflammatory markers, coagulation profile, D-Dimer and anti-T antigen were reported. Results Our data showed that patients with blood groups O and B are more protective against severe complications from COVID-19, as compared to patients with blood groups A and AB. This could be partially attributed to the presence of anti-T in blood group A individuals, compared to non-blood group A. Conclusion The current study reports an association between the ABO blood group and the susceptibility to severe complications from COVID-19, with a possible role of anti-T in driving the mechanism of the thrombotic tendency, as it was also correlated with an elevation in D-dimer levels.
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来源期刊
AIMS Medical Science
AIMS Medical Science MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
14.30%
发文量
20
审稿时长
12 weeks
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