脑溶素对糖尿病大鼠心脏神经病变的影响

Enedina Zurita, M. Huerta, Luis De Jesús, F. Cruz, R. Ortiz-Butrón, G. Flores, M. J. Gómez-Villalobos
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引用次数: 2

摘要

糖尿病患者心脏自主神经支配异常,导致心血管参数改变。脑溶素是一种神经营养因子,可改善脑损伤后中枢神经系统的树突状树和突触。本研究旨在探讨脑溶血素对糖尿病大鼠心脏神经病变的改善作用。2月龄雄性Sprague-Dawley大鼠注射链脲佐菌素(70 mg/Kg/, ip)。注射STZ 8周后确认出现高血糖和心率改变,对照组和糖尿病大鼠开始脑溶血素治疗2个月(1 ml/kg/天,ip)。测量体重、心率、心率变异性、动脉血压和血糖水平。同时测量左心室匀浆中心脏重量和亚硝酸盐、NGF和VEGF的水平。结果表明,糖尿病大鼠体重明显减轻,血糖水平明显升高。脑溶素治疗对对照组和糖尿病大鼠的体重和血糖水平均无显著影响。与糖尿病生理盐水组(272±8.9 lat/min, P < 0.05)相比,脑溶素治疗糖尿病大鼠的基础心率(306±6.5 lat/min)有所改善,对照组无变化。糖尿病脑溶素治疗大鼠左心室亚硝酸盐、VEGF和NGF水平升高。总之,结果表明,脑溶血素改善了糖尿病大鼠心脏神经病变中观察到的一些异常,并表明可以考虑作为预防或减少糖尿病引起的心脏自主神经改变的额外治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebrolysin Effects on Cardiac Neuropathy in Diabetic Rats
Autonomic innervation of heart is abnormal in diabetes and produces altered cardiovascular parameters. Cerebrolysin is a neurotrophic factor that improves the dendritic tree and synapses in the central nerve system after brain damage. The aim of this study was to evaluate if cerebrolysin can improve the cardiac neuropathy generated in diabetic rats. Male Sprague-Dawley rats two months old were injected with streptozotocin (70 mg/Kg/, ip). Hyperglycemia and altered cardiac rate were confirmed after eight weeks of STZ injection, and cerebrolysin treatment was started in control and diabetic rats for two months (1 ml/kg/day, ip). Body weight, heart rate, heart rate variability, arterial blood pressure, and blood glucose levels were measured. Also heart weight and levels of nitrites, NGF and VEGF were measured in left ventricle homogenates. The results show that body weight was reduced and blood glucose levels were increased significantly in diabetic rats. Cerebrolysin treatment produced no significant changes in body weight either in blood glucose level in control and diabetic rats. Cerebrolysin treatment in diabetic rats shows an improvement in the altered basal cardiac rate (306 ± 6.5 lat/min) compared to diabetic saline group (272 ± 8.9 lat/min: P < 0.05), without changes in control rats. Levels of nitrites, VEGF, and NGF in the left ventricle increased in diabetic cerebrolysin treated rats. In conclusion, the results show that cerebrolysin improves some abnormalities observed in the diabetic cardiac neuropathy in rats and suggest that could be considered an additional treatment to prevent or reduce the cardiac autonomic alterations generated in diabetes.
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