杂环的研究。十五。蝶啶-4-羧酸、-4-羧胺和-4-碳腈的合成及共价水合反应

Journal of The Chemical Society C: Organic Pub Date : 1971-01-01 DOI:10.1039/J39710000375

Jim D. Clark, W. Pendergast, F. S. Yates, A. Cunliffe

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引用次数: 2

摘要

蝶啶-4-羧酸乙酯水解得到相应的羧酸为5,6:7,8二水合物，不分解不能脱水。介绍了蝶啶-4-羧酰胺、n -乙基蝶啶-4-羧酰胺、6,7-二甲基蝶啶-4-羧酰胺和蝶啶-4-碳腈的合成，并讨论了这些化合物的共价水化行为。

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Heterocyclic studies. Part XV. Synthesis and covalent hydration of pteridine-4-carboxylic acid, -4-carboxamide, and -4-carbonitrile

Hydrolysis of ethyl pteridine-4-carboxylate gave the corresponding carboxylic acid as a 5,6:7,8-dihydrated species which could not be dehydrated without decomposition. Syntheses of pteridine-4-carboxamide, N-ethylpteridine-4-carboxamide, 6,7-dimethylpteridine-4-carboxamide, and pteridine-4-carbonitrile are described and the covalent hydration behaviour of these compounds is discussed.

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Journal of The Chemical Society C: Organic

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