滋养细胞JAR和JEG-3调节CD90 (Thy - 1)在蜕质细胞上的表达

IF 0.3 4区综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES

Comptes Rendus De L Academie Bulgare Des Sciences Pub Date : 2018-06-30 DOI:10.7546/CRABS.2018.06.10

K. Vinketova, I. Karaguozov, M. Mourdjeva, M. Sperandio, T. Oreshkova

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引用次数: 1

摘要

CD90是一种参与白细胞归巢和细胞分化的糖蛋白。在人子宫内膜中，CD90被描述为内皮细胞和基质细胞。如果怀孕，组织被免疫细胞和滋养细胞浸润，它们合作重塑组织。这个过程需要对细胞粘附和迁移进行精细的调节。用流式细胞术研究了CD90在体外培养的JAR和JEG-3细胞间质细胞中的表达及其在滋养细胞中通过可溶性因子的调节作用。一些细胞系普遍表达CD90，而另一些细胞系则同时表达CD90(高)和CD90(低)。此外，当蜕膜细胞通过可溶性因子与滋养细胞沟通时，CD90在蜕膜细胞上的表达减少。结果提示，滋养细胞引导的蜕质细胞分化可能影响免疫细胞的迁移和组织分布。

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Trophoblast Cell Lines JAR and JEG-3 Modulate CD90 (Thy‑1) Expression on Decidual Stromal Cells

CD90 is a glycoprotein involved in leukocyte homing and cell differentiation. In human endometrium CD90 is described on endothelial and stromal cells. If pregnancy occurs, the tissue is infiltrated by immune and trophoblast cells, which cooperate to remodel the tissue. The process requires a fine regulation of cell adhesion and migration. The expression of CD90 on cultured decidual stromal cells and its modulation by trophoblast cells from JAR and JEG-3 cell lines via soluble factors are investigated by flow cytometry. Some of decidual stromal cell lines showed ubiquitous expression of CD90 but in others a coexistence of CD90(high) and CD90(low) decidual stromal cells was observed. Further, a reduction of CD90 expression on decidual stromal cells was defined when decidual stromal cells communicate with trophoblast cells via soluble factors. The results sugguest a trophoblast guided differentiation of decidual stromal cells that could influence immune cells migration and tissue distribution.

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来源期刊

Comptes Rendus De L Academie Bulgare Des Sciences 综合性期刊-综合性期刊

CiteScore

0.60

自引率

33.30%

发文量

181

审稿时长

3-6 weeks

期刊介绍： Founded in 1948 by academician Georgy Nadjakov, "Comptes rendus de l’Académie bulgare des Sciences" is also known as "Доклади на БАН","Доклады Болгарской академии наук" and "Proceeding of the Bulgarian Academy of Sciences". If applicable, the name of the journal should be abbreviated as follows: C. R. Acad. Bulg. Sci. (according to ISO)