树突状细胞——战胜艾滋病毒。

IF 2.1 4区 医学 Q4 CELL & TISSUE ENGINEERING
Naresh Poondla, Mohsen Sheykhhasan, Yaghoub Ahmadyousefi, Mohammad Akbari, Reihaneh Seyedebrahimi, Mohsen Eslami Farsani, Naser Kalhor
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引用次数: 0

摘要

HIV是一种针对并劫持宿主免疫细胞的病毒。它通过攻击辅助t淋巴细胞而增殖。由于无法找到成功的治疗方法和无法获得医疗保健,艾滋病毒仍然是世界上最困难和最危险的感染之一。当病毒到达人体时,树突细胞是它遇到的第一个细胞。树突状细胞已被确定为最有效的免疫反应介质之一,这意味着对抗病毒感染的有希望的策略。目前关于树突状细胞及其亚群功能的知识状况对于充分利用它们作为开发艾滋病毒疫苗的候选物的潜力至关重要。尽管进行了广泛的努力,但尚未找到一种副作用最少的可靠疫苗,需要进一步研究以找到一种可靠和有效的疫苗。在多大程度上,树突状细胞为基础的治疗是用于治疗艾滋病毒进行了研究。当病毒攻击宿主免疫系统时,树突状细胞可以触发针对HIV-1感染的免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dendritic Cells - Winning the Fight against HIV.

HIV is a virus that targets and hijacks the immune cells of the host. It multiplies by attacking the helper T-lymphocytes. HIV has remained one of the most difficult and dangerous infections in the world due to the inability to find a successful treatment and a lack of access to medical care. When the virus reaches the body, dendritic cells are the first cells it encounters. DCs have been identified as one of the most effective mediators of immune responses, implying a promising strategy against viral infection. The current state of knowledge about the function of dendritic cells and their subsets is critical for using their full potential as a candidate for the development of an HIV vaccine. Despite extensive efforts, a reliable vaccine with the fewest side effects has yet to be found, and further research is needed to find a dependable and efficient vaccine. The extent to which dendritic cell-based therapy is used to treat HIV was investigated in this study. As the virus attacks the host immune system, the dendritic cells can trigger an immune response against HIV-1 infection.

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来源期刊
Current stem cell research & therapy
Current stem cell research & therapy CELL & TISSUE ENGINEERING-CELL BIOLOGY
CiteScore
4.20
自引率
3.70%
发文量
197
审稿时长
>12 weeks
期刊介绍: Current Stem Cell Research & Therapy publishes high quality frontier reviews, drug clinical trial studies and guest edited issues on all aspects of basic research on stem cells and their uses in clinical therapy. The journal is essential reading for all researchers and clinicians involved in stem cells research.
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