Concentrés plaquettaires : technologies, biologie associée, applications cliniques, analyses histologiques 3e partie : applications cliniques

The search for protocols supporting the haemostasis and the cicatrisation is a recurring problem in all the surgical disciplines. The platelet concentrates, as biological adhesives enriched in cytokines, were used in a multitude of clinical situations in order to evaluate their supposed effects. In ophthalmology, they were added to the surgical treatment of macular holes. In plastic surgery, they are used as fibrin adhesives in order to prevent the formation of keloid scars, which aesthetic and mechanical qualities are very prejudicial. In periodontal, peri-implant and maxillo-facial surgeries, they play the biological role of link between various elements during bone grafts or gingival surgeries and the role of protective seal in the operational site, as well as the fibrin adhesives used before. However, published works suffer from many skews and the really scientific absence of methodology to evaluate the range of it. And these analytical gaps reinforce the doubts as for the biological identity of these preparations: platelet gel or fibrin adhesive?