肥胖和超重儿童主动脉弹性参数的评估。

IF 0.8 4区医学 Q4 PEDIATRICS

Turkish Journal of Pediatrics Pub Date : 2023-01-01 DOI:10.24953/turkjped.2020.3365

Noor Mohammad Noori, Maryam Nakhaei-Moghadam, Alireza Teimouri

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引用次数: 0

摘要

背景:主动脉弹性是儿童未来心血管事件的预测因子和公认因素。这项研究的目的是评估肥胖和超重儿童与健康儿童相比的主动脉僵硬程度。方法:研究评估了98名性别匹配的4 ~ 16岁儿童，这些儿童平均分布在无症状肥胖或超重儿童组和健康儿童组。所有的参与者都没有心脏疾病。采用二维超声心动图测定动脉僵硬指数。结果:肥胖儿童和健康儿童的平均年龄分别为10.40±2.50岁和10.06±1.53岁。肥胖儿童主动脉压力(20.70±5.04%)高于健康儿童(7.06±3.77%)和超重儿童(18.59±8.08%，p < 0.001)。肥胖儿童的主动脉膨胀性(AD)(0.010±0.005 cm 2 dyn-1x10-6)显著高于健康儿童(0.0036±0.004 cm 2 dyn-1x10 -6 )和超重儿童(0.009±0.005 cm 2 dyn-1x10 -6, p < 0.001)。正常儿童主动脉应变β (ASβ)指数(9.26±6.17)明显高于正常儿童。正常儿童压力-应变弹性模量(PSEM)显著高于正常儿童(7.52±4.76 kPa)。收缩压随体重指数(BMI)显著升高(p < 0.001)，舒张压无变化(p=0.143)。BMI对动脉硬度(AS) (β=0.732, p < 0.001)、AD (β=0.636, p < 0.001)、ASβ指数(β=-0.573, p < 0.001)和PSEM (β=-0.578, p < 0.001)均有显著影响。年龄对主动脉收缩期内径(β=0.340, p < 0.001)和舒张期内径(β=0.407, p < 0.001)有显著影响。结论:肥胖儿童主动脉应变β指数和主动脉PSEM降低时，主动脉应变和主动脉扩张性增加。这一结果表明，由于心房僵硬是未来心脏病的一个预测指标，对于超重或肥胖儿童的饮食治疗是重要的。

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Assessment of aortic elasticity parameters in obese and overweight children.

Background: Aortic elasticity is a predictor and recognized factor for future cardiovascular events in children. The aim of the study was to evaluate the aortic stiffness in obese and overweight children compared to healthy ones.

Methods: The study evaluated 98 sex matched children aged 4 to 16 years that were equally distributed in asymptomatic obese or overweight and healthy children groups. All the participants were free of any heart diseases. Arterial stiffness indices were determined using two-dimensional echocardiography.

Results: The mean ages in the obese and healthy children were 10.40±2.50 years and 10.06±1.53 years, respectively. Aortic strain was significantly higher in obese children (20.70±5.04%), compared to healthy (7.06±3.77%) and overweight children (18.59±8.08%, p < 0.001). Aortic distensibility (AD) was significantly higher in obese children (0.010±0.005 cm 2 dyn-1x10-6), compared to healthy (0.0036±0.004 cm 2 dyn-1x10 -6 ) and overweight children (0.009±0.005 cm 2 dyn-1x10 -6 , p < 0.001). Aortic strain beta (ASβ) index, was significantly higher in healthy children (9.26±6.17). Pressure-strain elastic modulus (PSEM) was significantly higher in healthy children (7.52±4.76 kPa). Systolic blood pressure increased with body mass index (BMI) significantly (p < 0.001) but diastolic blood pressure did not change (p=0.143). BMI had significant effect on arterial stiffness (AS) (β=0.732, p < 0.001), AD (β=0.636, p < 0.001), ASβ index (β=-0.573, p < 0.001) and PSEM (β=-0.578, p < 0.001). Age had significant effect on systolic diameter of the aorta (β=0.340, p < 0.001) and diastolic diameter of the aorta (β=0.407, p < 0.001).

Conclusions: We concluded that aortic strain and aortic distensibility increased in obese children when aortic strain beta index and PSEM decreased. This result suggests that, as atrial stiffness is a predictor for future heart diseases, dietary treatment for children with overweight or obese status is important.

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来源期刊

Turkish Journal of Pediatrics 医学-小儿科

CiteScore

1.40

自引率

0.00%

发文量

122

审稿时长

6-12 weeks

期刊介绍： The Turkish Journal of Pediatrics is a multidisciplinary, peer reviewed, open access journal that seeks to publish research to advance the field of Pediatrics. The Journal publishes original articles, case reports, review of the literature, short communications, clinicopathological exercises and letter to the editor in the field of pediatrics. Articles published in this journal are evaluated in an independent and unbiased, double blinded peer-reviewed fashion by an advisory committee.