茯苓提取物对瑞士白化病小鼠的镇痛作用

Sylvia Opiyo, K. Muna, P. Njoroge, Ephantus G. Ndirangu
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引用次数: 3

摘要

传统医学在控制感染方面仍然发挥着重要作用,特别是在非洲。Conyza floribunda Kunth的提取物用于治疗喉咙痛,癣和其他皮肤相关感染,牙痛和止血。据报道,该植物的提取物具有抗菌和抗真菌活性。以前对这种植物进行的植物化学研究产生了萜类、甾醇和类黄酮。本研究的目的是测定花参提取物的镇痛活性。用瑞士白化病小鼠进行甲醇、DCM和正己烷提取物的毒性、热板潜伏期和醋酸致扭体实验。该植物提取物在热板潜伏期和醋酸扭体实验中均表现出镇痛活性。与阴性对照相比,提取物显著增加了动物的反应时间。在热板潜伏期实验中,随着时间的推移,提取物和吗啡的镇痛活性呈上升趋势,在90分钟时达到峰值,随后下降。在醋酸诱导扭体试验中,与阴性对照组相比,给予植物提取物显著减少了腹部收缩的次数。甲醇、DCM和正己烷提取物对腹部收缩的抑制率分别为67.2、46.5和39.4%。本研究的发现证实了民间关于花楸提取物具有镇痛作用的说法。因此,我们建议从植物提取物用于疼痛管理。进一步的研究应进行分离和表征从植物的镇痛原理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analgesic Activity of Conyza Floribunda Extracts in Swiss Albino Mice
Traditional medicine still plays an important role in managing infections especially in Africa. Extracts of Conyza floribunda Kunth are used to treat sore throat, ringworm and other skin related infections, toothache and to stop bleeding from injuries. Extracts from the plant have been reported to exhibit antibacterial and antifungal activities. Previous phytochemical studies on the plant yielded terpenoid, sterols and flavonoids. The aim of the present study was to determine the analgesic activity Conyza floribunda extracts. Methanol, DCM and n -hexane extracts of the plant were subjects to toxicity, hot plate latency and acetic acid induced-writhing tests using Swiss Albino Mice. The plant extract showed analgesic activity in both hot plate latency and acetic acid induced-writhing tests. The extracts significantly increased the response time in the animals compared to the negative control. In the hot plate latency test, the analgesic activity of the extracts and that of morphine rose over time to peak at 90 minutes and then decreased afterwards. In the acetic acid-induces writhing test, administration of the plant extracts significantly reduced the number of abdominal contractions compared to the negative control. The percentage inhibitions of abdominal contractions were 67.2, 46.5 and 39.4 for methanol, DCM and n -hexane extracts respectively. The findings from this study have confirmed the folkloric information that extracts from C. floribunda have analgesic properties. We therefore recommend the extracts from the plant for use in pain management. Further studies should be carried out to isolate and characterize the analgesic principles from the plant.
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