小檗碱在肺组织中的免疫调节和抗炎作用及其在COVID-19预防和治疗中的潜在应用

IF 3.1 4区 生物学 Q2 Immunology and Microbiology
A. Majdalawieh, Sarah M Yousef, I. Abu-Yousef, G. Nasrallah
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引用次数: 3

摘要

具有已知安全性的天然产物是发现新药线索的有希望的来源。小檗碱就是这样一种植物化学物质,由于其抗炎和免疫调节特性而被广泛研究,可以对抗从呼吸系统疾病到病毒感染等多种疾病。越来越多的研究支持小檗碱可能在对抗可怕的COVID-19疾病中发挥多能治疗作用。COVID-19的确切病理生理特征尚未阐明。然而,令人信服的证据表明,炎症和免疫失调是本病的主要特征。作为一种有效的免疫调节和抗炎剂,小檗碱可能被证明对预防和治疗COVID-19有用。本综述旨在回顾小檗碱对多种呼吸道感染(如COVID-19)的药理抗炎和免疫调节作用,这些感染已知会对呼吸道和肺部产生不利影响。我们推测小檗碱可能通过阻止细胞因子风暴、恢复Th1/Th2平衡和增强细胞介导的免疫来帮助缓解COVID-19。此外,这种有前途的植物化学物质在其他重要的炎症介质中所起的作用将被强调。我们进一步强调了小檗碱对COVID-19的作用,强调了来自硅、体外和体内研究的直接证据,表明小檗碱可能对SARS-CoV-2的三个关键靶点起抑制作用,即主要蛋白酶、刺突蛋白和血管紧张素转换酶2受体。当然,还需要进一步的临床前和临床试验来进一步证实小檗碱对人类COVID-19的疗效和效力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19.
Natural products with known safety profiles are a promising source for the discovery of new drug leads. Berberine presents an example of one such phytochemical that has been extensively studied for its anti-inflammatory and immunomodulatory properties against myriads of diseases, ranging from respiratory disorders to viral infections. A growing body of research supports the pluripotent therapeutic role berberine may play against the dreaded disease COVID-19. The exact pathophysiological features of COVID-19 are yet to be elucidated. However, compelling evidence suggests inflammation and immune dysregulations as major features of this disease. Being a potent immunomodulatory and anti-inflammatory agent, berberine may prove to be useful for the prevention and treatment of COVID-19. This review aims to revisit the pharmacological anti-inflammatory and immunomodulatory benefits of berberine on a multitude of respiratory infections, which like COVID-19, are known to adversely affect the airways and lungs. We speculate that berberine may help alleviate COVID-19 via preventing cytokine storm, restoring Th1/Th2 balance, and enhancing cell-mediated immunity. Furthermore, the role this promising phytochemical plays on other important inflammatory mediators involved in respiratory disorders will be underscored. We further highlight the role of berberine against COVID-19 by underscoring direct evidence from in silico, in vitro, and in vivo studies suggesting the inhibitory potential berberine may play against three critical SARS-CoV-2 targets, namely main protease, spike protein, and angiotensin-converting enzyme 2 receptor. Further preclinical and clinical trials are certainly required to further substantiate the efficacy and potency of berberine against COVID-19 in humans.
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来源期刊
Frontiers in Bioscience-Landmark
Frontiers in Bioscience-Landmark 生物-生化与分子生物学
CiteScore
3.40
自引率
3.20%
发文量
301
审稿时长
3 months
期刊介绍: FBL is an international peer-reviewed open access journal of biological and medical science. FBL publishes state of the art advances in any discipline in the area of biology and medicine, including biochemistry and molecular biology, parasitology, virology, immunology, epidemiology, microbiology, entomology, botany, agronomy, as well as basic medicine, preventive medicine, bioinformatics and other related topics.
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