多发性硬化症微循环因子患者的心血管危险疾病

M. Al-Ahmad
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摘要

多发性硬化症(MS)是一种神经退行性疾病,影响局点感觉系统(CNS),挽救边缘感觉系统,并在成年早期发现其最初迹象,其临床过程从无害状态到迅速发展为衰弱性感染。多发性硬化症是公认的最广泛的中枢神经系统感染,也是年轻人神经障碍最广为人知的原因,全球约有250万人受到影响,具有可变运动和猜测。在不同的地区和人群中,多发性硬化的发生和普遍速度发生了显著的变化,显示出一种可能是由于遗传和社会变异造成的磨坊纬度斜率。欧洲被视为多发性硬化症的高复发地区(优势≥30/100,000);其他高患病率地区包括美国北部、以色列、加拿大、南澳大利亚、新西兰和俄罗斯东部。持续恶化、静脉周围结合、脱髓鞘、神经胶质瘤和神经元不幸是病理的迹象,在白质和大脑皮层中产生斑块发育和组织湮灭。尽管免疫学和原子科学取得了重大进展,但人们对多发性硬化症的病因知之甚少,其耐药的触发和因果途径也很模糊。此外,病因病理学仪器如何影响这种疾病的进程仍然不清楚。有吸引力的混响成像(MRI)的研究表明,白质损伤与神经障碍相对应,包括MS患者在内的纵向检查显示,由于暗质溃疡,暗物质的衰变速度加快。暗物质衰变比白质衰变更明确地与生理和心理障碍相对应。人们提出了许多假设,并区分了许多潜在的原因:遗传倾向、生态成分、污染、血管危险因素和可怕的精神伤害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiovascular Danger Disease in Patients with Microcirculation Factors in Multiple Sclerosis
Different sclerosis (MS) is a neurodegenerative issue that influences the focal sensory system (CNS), saving the fringe sensory system and uncovering its first signs in early adulthood, with a variable clinical course going from a harmless condition to a quickly developing debilitating infection. MS is the most widely recognized infection of the CNS and the most well-known reason for neurological handicap in youthful grown-ups, influencing around 2.5 million around the world, with variable movement and guess. The occurrence and commonness paces of MS shift significantly among locales and populaces, showing a run of the mill latitudinal slope most likely because of hereditary and social varieties. Europe is viewed as a high recurrence region for MS (predominance ≥ 30/100,000); other high commonness locales incorporate the northern USA, Israel, Canada, Southern Australia, New Zealand and Eastern Russia. Constant aggravation, perivenular binding, demyelization, gliosis and neuronal misfortune are signs of the pathology, creating plaque development and tissue annihilation in the white matter as well as in the cerebral cortex. In spite of significant advances in immunology and atomic science, MS is ineffectively perceived concerning etiology and its resistant trigger and causal pathways are generously obscure. Additionally, how etiopathological instruments impact the course of this illness stays indistinct. Studies with attractive reverberation imaging (MRI) have exhibited that white matter injuries correspond feebly with neurological handicap and longitudinal examinations including MS patients have shown sped up dark matter decay as result of dim matter sores. Dark matter (GM) decay corresponds with physical and psychological handicap more unequivocally than white matter decay. Numerous hypotheses have been created, and numerous potential causes have been distinguished: hereditary inclination, ecological components, contaminations, vascular danger factors, and horrible mind injury.
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