2-[(E)-(4-羟基-3-{(E)-[(喹啉-2-基)亚氨基]甲基}苯基)二氮基]苯甲酸的二丁基锡配合物:合成、光谱及体外抗真菌活性

IF 1 4区工程技术 Q4 CHEMISTRY, MULTIDISCIPLINARY

Iranian Journal of Chemistry & Chemical Engineering-international English Edition Pub Date : 2021-09-19 DOI:10.30492/IJCCE.2021.532179.4793

M. Roy, Jhinuk De

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引用次数: 0

摘要

摘要:采用2-[(E)-(4)-(4-羟基-3-{(E)-[(喹啉-2-基)亚胺]甲基}苯基)二氮基]苯甲酸与氧化二丁基锡(IV)在热甲苯中回流法制备了2-[(E)-(4)- 3-{(E)-[(喹啉-2-基)亚胺]甲基}苯基)二氮基]苯甲酸二丁基锡(IV)配合物。结合uv -可见、IR、1H、13C、119Sn NMR和质谱技术对配合物进行了元素分析。羧酸配体与配合物中的锡原子形成螯合双齿配位模式。该配合物在溶液状态下表现为环状二聚体结构，锡中心呈六坐标八面体结构。观察配体和配合物的体外抗真菌性能，并与对照药物两性霉素b进行比较。

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Dibutyltin(IV) complex of 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid: Synthesis, spectroscopy and in vitro antifungal activity

ABSTRACT: Dibutyltin(IV) complex of 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid was synthesized by refluxing 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2- yl) imino] methyl} phenyl) diazenyl]benzoic acid with dibutyltin(IV) oxide in hot toluene. The complex was characterized by elemental analysis in combination with UV-visible, IR, 1H, 13C, 119Sn NMR spectroscopy and Mass spectrometry technique. The carboxylate ligand acts as chelating bidentate mode of coordination with the tin atom in the complex. The complex exhibited cyclic dimeric structure in the solution state where the tin centers adopt 6- coordinate octahedral geometry. The in vitro antifungal property of the ligand and the complex was observed and compared with reference drug, Amphotericin-B.

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来源期刊

Iranian Journal of Chemistry & Chemical Engineering-international English Edition CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

2.80

自引率

22.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of the Iranian Journal of Chemistry and Chemical Engineering is to foster the growth of educational, scientific and Industrial Research activities among chemists and chemical engineers and to provide a medium for mutual communication and relations between Iranian academia and the industry on the one hand, and the world the scientific community on the other.