基于纳米技术克服肿瘤微环境缺氧策略的最新进展。

IF 3.1 4区生物学 Q2 Immunology and Microbiology

Frontiers in Bioscience-Landmark Pub Date : 2022-05-06 DOI:10.31083/j.fbl2705145

Jiangchao Wu, Jinyuan Song, Xianghong Yin, Jianghui Tang, Junlei Zhang, Xun Wang, Yongtao Ji, Yaxing Zhao, Dong-Xue Chen, Jianpeng Sheng, X. Bai, T. Liang

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引用次数: 5

摘要

缺氧是大多数实体恶性肿瘤的典型特征，对肿瘤的恶性表型和生物学行为有多种影响，包括上皮-间质-转化(epithelial-mesenchymal-transition, EMT)、侵袭、迁移、转移、自噬、干细胞维持、病理性血管生成、耐药、免疫抑制等。最近，通过纳米技术逆转肿瘤缺氧环境已经成为治疗恶性肿瘤的一种新的治疗方法。纳米技术缓解或改善缺氧环境的主要策略有:(1)向肿瘤缺氧微环境引入外氧;(2)纳米技术就地制氧;(3)调节肿瘤微环境结构;(4)降低肿瘤微环境的耗氧量。在这篇综述中，我们将详细讨论这些纳米技术。

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Recent Advancements of Nanotechnology-Based Strategies for Overcoming Tumor Microenvironment Hypoxia.

Hypoxia is a typical characteristic of most solid malignancies, which has multiple effects on malignant phenotypes and biological behaviors of tumors including epithelial-mesenchymal-transition (EMT), invasion, migration, metastasis, autophagy, stem cell maintenance, pathological angiogenesis, drug resistance, and immunosuppression. Rcentlyumoand reversing the tumor hypoxic environment via nanotechnology has emerged as a novel therapeutic approach for the treatment of malignancies. The main strategies related to nanotechnology to alleviate or ameliorate hypoxic environment are as follows: (1) Bringing external oxygen to tumor hypoxic microenvironment; (2) Generating oxygen based on nanotechnology in situ; (3) Regulating the structure of the tumor microenvironment; (4) Decreasing oxygen consumption in the tumor microenvironment. In this review, we will discuss these nanotechnologies in detail.

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来源期刊

Frontiers in Bioscience-Landmark 生物-生化与分子生物学

CiteScore

3.40

自引率

3.20%

发文量

301

审稿时长

3 months

期刊介绍： FBL is an international peer-reviewed open access journal of biological and medical science. FBL publishes state of the art advances in any discipline in the area of biology and medicine, including biochemistry and molecular biology, parasitology, virology, immunology, epidemiology, microbiology, entomology, botany, agronomy, as well as basic medicine, preventive medicine, bioinformatics and other related topics.