{"title":"蛋白质和白蛋白","authors":"R. Bertholf","doi":"10.1309/LMKRNRGW5J03APZQ","DOIUrl":null,"url":null,"abstract":"Proteins are large polymers of amino acids linked by peptide bonds (Figure 1). The amino acid subunits of proteins are organic molecules that include a carboxylic acid linked through a carbon atom to a primary (or secondary, in proline) amine with the chemical formula H 2 N-CHR-COOH, in which R is a side group that largely determines the chemical properties of the amino acid. The simplest amino acid is glycine, H 2 N-CH 2 -COOH, in which the R side group is a hydrogen atom. Although this chemical template can be modified into an infinite array of molecules based on variations in the R group, only approximately 20 amino acids occur in proteins. The R groups confer acidic, alkaline, polar, or nonpolar properties to the various amino acids.","PeriodicalId":54328,"journal":{"name":"Labmedicine","volume":"21 1","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"19","resultStr":"{\"title\":\"Proteins and Albumin\",\"authors\":\"R. Bertholf\",\"doi\":\"10.1309/LMKRNRGW5J03APZQ\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Proteins are large polymers of amino acids linked by peptide bonds (Figure 1). The amino acid subunits of proteins are organic molecules that include a carboxylic acid linked through a carbon atom to a primary (or secondary, in proline) amine with the chemical formula H 2 N-CHR-COOH, in which R is a side group that largely determines the chemical properties of the amino acid. The simplest amino acid is glycine, H 2 N-CH 2 -COOH, in which the R side group is a hydrogen atom. Although this chemical template can be modified into an infinite array of molecules based on variations in the R group, only approximately 20 amino acids occur in proteins. The R groups confer acidic, alkaline, polar, or nonpolar properties to the various amino acids.\",\"PeriodicalId\":54328,\"journal\":{\"name\":\"Labmedicine\",\"volume\":\"21 1\",\"pages\":\"\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2014-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Labmedicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1309/LMKRNRGW5J03APZQ\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Labmedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1309/LMKRNRGW5J03APZQ","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 19
摘要
蛋白质是由肽键连接的氨基酸的大聚合物(图1)。蛋白质的氨基酸亚基是有机分子,包括一个羧酸,通过一个碳原子连接到一个伯胺(或脯氨酸中的仲胺),化学式为h2 n - cr - cooh,其中R是一个侧基,在很大程度上决定了氨基酸的化学性质。最简单的氨基酸是甘氨酸H 2 N-CH 2 -COOH,它的R侧基是一个氢原子。尽管这种化学模板可以根据R基团的变化被修饰成无限的分子阵列,但蛋白质中只有大约20个氨基酸。R基团赋予各种氨基酸酸性、碱性、极性或非极性的性质。
Proteins are large polymers of amino acids linked by peptide bonds (Figure 1). The amino acid subunits of proteins are organic molecules that include a carboxylic acid linked through a carbon atom to a primary (or secondary, in proline) amine with the chemical formula H 2 N-CHR-COOH, in which R is a side group that largely determines the chemical properties of the amino acid. The simplest amino acid is glycine, H 2 N-CH 2 -COOH, in which the R side group is a hydrogen atom. Although this chemical template can be modified into an infinite array of molecules based on variations in the R group, only approximately 20 amino acids occur in proteins. The R groups confer acidic, alkaline, polar, or nonpolar properties to the various amino acids.
期刊介绍:
Lab Medicine is a peer-reviewed biomedical journal published quarterly by the ASCP and Oxford University Press. The journal invites submission of manuscripts on topics related to clinical chemistry and microbiology, hematology, immunology, transfusion medicine, molecular diagnostics, cytology, histology, and laboratory administration and management. Original research, reviews, and case reports are considered for publication. Lab Medicine is indexed (under the title Laboratory Medicine) by the National Library of Medicine and is included in the PubMed database.