克服药物消化过程副作用的研究进展

M. Farhan, Abdul Majeed, Nuha A. Imran, W. Al-Zuhairi, Leqaa A. Mohammed
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引用次数: 1

摘要

本文综述了消化方式对药物的影响,以及如何通过设计一种合适的聚合物药物体系来克服消化过程的危害,这种聚合物药物体系能够承受胃酸的恶劣条件。它涉及到不同类型的骨架聚合物来制备新的药物聚合物形式,这种新的聚合物药物具有许多优点,如通过有组织的给药,在较长时间内释放最少的药物,减少药物的副作用。该工艺包括用间隔剂对壳聚糖、淀粉、纤维素、明胶等天然聚合物进行改性,并与氨基药物阿莫西林(HA)接枝,用紫外光谱(DSC)和热重分析(TGA)对其进行表征,并对其物理性质进行了讨论。并了解药物在不同ph下的释放能力。本文认为,将药物作为高分子药物使用是克服消化过程中药物副作用的最佳方法,而高分子药物的最佳聚合物是天然聚合物,制备的高分子药物比单独使用的药物具有更大的热稳定性,这表明药物的有效期更长,药物的安全性更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review of Overcome the Side Effect of Digestion Process on the Drugs
This review involves the effect of digestion methods on the drugs and how to overcome the harms of digestion process by designing the suitable a polymeric drug system that has ability to hold out the harsh conditions of the acid in stomach. And it involves different type of backbone polymer to prepare new drug polymers form, this new polymer drugs included many benefits such as release the minimum amount of drug over an prolonged time by organized delivery of drug and the side effect of drugs will reduced. This process includes the modification of natural polymer such as chitosan, starch, cellulose, gelatin by carried out with a spacer, and grafted the new copolymer with amino drug such as amoxicillin (HA), and characterize it by UV Spectroscopes, (DSC) and (TGA) and physical properties was discussed. And know the ability of drug release in different pH. In this review we concluded that the best way to overcome the side effect of digestion process on the drugs by using the medicine as polymer drugs, and the best polymer used was natural polymers, the prepared polymer drug have thermal stability more than the drug alone, this indicate extra expire date with more safety of drug satiability.
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