肺动脉高压对终末期COPD患者生存的影响

A. Kapasi, K. Halloran, A. Hirji, D. Lien, J. Mooney, R. Raj, A. Sweatt, J. Weinkauf, R. Zamanian
{"title":"肺动脉高压对终末期COPD患者生存的影响","authors":"A. Kapasi, K. Halloran, A. Hirji, D. Lien, J. Mooney, R. Raj, A. Sweatt, J. Weinkauf, R. Zamanian","doi":"10.1183/13993003.congress-2019.pa1426","DOIUrl":null,"url":null,"abstract":"Pulmonary hypertension (PH) is a common finding in chronic obstructive pulmonary disease (COPD) and is associated with poor outcomes. Our objective was to evaluate the survival implications of PH in end-stage COPD. Methods: We performed a retrospective review of adult COPD patients in the Scientific Registry of Transplant Recipients between Jan 2005 and Dec 2014. Patients were classified as:\n PH absent (mean pulmonary artery pressure (mPAP) Borderline PH, preserved pulmonary vascular resistance (PVR) (mPAP 21-24 mmHg, PVR Borderline PH, high PVR (PVR ≥3 WU) PH, non-elevated PVR (mPAP 25-34 mmHg, PVR PH, high PVR (PVR ≥3 WU) Severe PH (mPAP ≥35 mmHg) Groups were evaluated by log rank test and Cox regression modeling. Patients were censored at transplant. Results: Of 4339 patients, 2287 (53%) had PH, 438 (10%) had severe PH, and 1229 died. Median survival was 4.5y (95% CI 4.1-5y) in group 1, and 2.8y (95% CI 2.5-3.6y) in group 6 (p Conclusions: COPD patients with borderline PH and PH had similarly increased risks of death (regardless of PVR), and those with severe PH had a further increase in risk. These findings are distinct from other lung diseases such as IPF, and suggest the need for a separate ontology for COPD-PH.","PeriodicalId":20724,"journal":{"name":"Pulmonary hypertension","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Survival implications of pulmonary hypertension in end-stage COPD\",\"authors\":\"A. Kapasi, K. Halloran, A. Hirji, D. Lien, J. Mooney, R. Raj, A. Sweatt, J. Weinkauf, R. Zamanian\",\"doi\":\"10.1183/13993003.congress-2019.pa1426\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Pulmonary hypertension (PH) is a common finding in chronic obstructive pulmonary disease (COPD) and is associated with poor outcomes. Our objective was to evaluate the survival implications of PH in end-stage COPD. Methods: We performed a retrospective review of adult COPD patients in the Scientific Registry of Transplant Recipients between Jan 2005 and Dec 2014. Patients were classified as:\\n PH absent (mean pulmonary artery pressure (mPAP) Borderline PH, preserved pulmonary vascular resistance (PVR) (mPAP 21-24 mmHg, PVR Borderline PH, high PVR (PVR ≥3 WU) PH, non-elevated PVR (mPAP 25-34 mmHg, PVR PH, high PVR (PVR ≥3 WU) Severe PH (mPAP ≥35 mmHg) Groups were evaluated by log rank test and Cox regression modeling. Patients were censored at transplant. Results: Of 4339 patients, 2287 (53%) had PH, 438 (10%) had severe PH, and 1229 died. Median survival was 4.5y (95% CI 4.1-5y) in group 1, and 2.8y (95% CI 2.5-3.6y) in group 6 (p Conclusions: COPD patients with borderline PH and PH had similarly increased risks of death (regardless of PVR), and those with severe PH had a further increase in risk. These findings are distinct from other lung diseases such as IPF, and suggest the need for a separate ontology for COPD-PH.\",\"PeriodicalId\":20724,\"journal\":{\"name\":\"Pulmonary hypertension\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pulmonary hypertension\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1183/13993003.congress-2019.pa1426\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pulmonary hypertension","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1183/13993003.congress-2019.pa1426","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

肺动脉高压(PH)是慢性阻塞性肺疾病(COPD)的常见发现,并与不良预后相关。我们的目的是评估PH对终末期COPD患者生存的影响。方法:我们对2005年1月至2014年12月间移植受者科学登记处的成年COPD患者进行了回顾性研究。将患者分为:PH缺失(平均肺动脉压(mPAP))、边缘PH、保留肺血管阻力(PVR) (mPAP 21-24 mmHg、PVR边缘PH、高PVR (PVR≥3wu) PH、非升高PVR (mPAP 25-34 mmHg、PVR PH、高PVR (PVR≥3wu)、严重PH (mPAP≥35 mmHg)组,采用log rank检验和Cox回归建模进行评价。病人在移植时受到审查。结果:4339例患者中,有PH 2287例(53%),重度PH 438例(10%),死亡1229例。第1组的中位生存期为4.5年(95% CI 4.1-5y),第6组的中位生存期为2.8年(95% CI 2.5-3.6y) (p)。结论:伴有边缘性PH和PH的COPD患者的死亡风险相似(与PVR无关),而严重PH患者的风险进一步增加。这些发现与其他肺部疾病(如IPF)不同,提示COPD-PH需要单独的本体论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Survival implications of pulmonary hypertension in end-stage COPD
Pulmonary hypertension (PH) is a common finding in chronic obstructive pulmonary disease (COPD) and is associated with poor outcomes. Our objective was to evaluate the survival implications of PH in end-stage COPD. Methods: We performed a retrospective review of adult COPD patients in the Scientific Registry of Transplant Recipients between Jan 2005 and Dec 2014. Patients were classified as: PH absent (mean pulmonary artery pressure (mPAP) Borderline PH, preserved pulmonary vascular resistance (PVR) (mPAP 21-24 mmHg, PVR Borderline PH, high PVR (PVR ≥3 WU) PH, non-elevated PVR (mPAP 25-34 mmHg, PVR PH, high PVR (PVR ≥3 WU) Severe PH (mPAP ≥35 mmHg) Groups were evaluated by log rank test and Cox regression modeling. Patients were censored at transplant. Results: Of 4339 patients, 2287 (53%) had PH, 438 (10%) had severe PH, and 1229 died. Median survival was 4.5y (95% CI 4.1-5y) in group 1, and 2.8y (95% CI 2.5-3.6y) in group 6 (p Conclusions: COPD patients with borderline PH and PH had similarly increased risks of death (regardless of PVR), and those with severe PH had a further increase in risk. These findings are distinct from other lung diseases such as IPF, and suggest the need for a separate ontology for COPD-PH.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信