严重晒伤是3种常见皮肤癌的主要危险因素:新的预防策略

W. L. Chiou
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摘要

Wu等人对已发表的两项大型前瞻性队列研究数据进行了重新分析,可能提供了迄今为止最明确的证据,即严重晒伤(SS)是男性和女性黑色素瘤、基底细胞癌(BCC)和鳞状细胞癌(SCC)所有发病率的压倒性危险因素(bbb90 %)。例如,研究发现,经历1-5次和≥6次SSs的男性患黑色素瘤的风险分别增加12.7倍和22倍。由于在强烈的间歇性阳光照射下使用防晒霜会导致意外的SS,这是一种错误的安全现象,防晒霜可以被认为是导致皮肤癌的潜在主要风险因素。因为长期暴露在非灼烧性的阳光下可以预防黑色素瘤并增强免疫力,这种保护作用也可能发生在不太严重的BCC和SCC中。因此,经常暴露在不灼烧的阳光下可能是预防皮肤癌和促进整体健康的新策略。理论上说,除了增强免疫力之外,经常暴露在没有灼伤的阳光下可以使皮肤晒黑,从而防止晒伤,从而预防皮肤癌。红斑,一种轻微的晒伤,在癌症发病率中的作用可能相对有限。由于普通人的皮肤老化可能主要是由内在因素引起的,而SS主要是由强烈的紫外线(UV) B射线引起的,因此可能需要重新考虑是否需要使用广谱防晒霜或有机防晒霜成分来防止UVA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Severe Sunburn as the Overwhelming Risk Factor for 3 Common Skin Cancers: New Prevention Strategy
Re-analysis of published data from two large prospective cohort studies by Wu, et al., probably provides the hitherto most unequivocal evidence that Severe Sunburn (SS) was an overwhelming risk factor (>90%) for all incidences of melanoma, Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) in both men and women. It is found, for example, that experiencing 1-5 and ≥ 6 SSs increased one’s risk for melanoma in men by 12.7-fold and 22fold, respectively. Since use of sunscreen during intense intermittent sun exposure can cause unintended SS, a false security phenomenon, sunscreen can be postulated as a potential major risk factor for causing skin cancers. Because chronic exposure to non-burning sunlight is protective against melanoma and can enhance immunity, this protective effect may also likely occur with less serious BCC and SCC. Therefore, regular exposure to non-burning sunlight may serve as a new strategy for skin cancer prevention and general health promotion. It is theorized that in addition to immunity enhancement, regular exposure to non-burning sunlight can result in skin tanning that will protect against sunburn and thereby protect against skin cancer. The role of erythema, a mild sunburn, in cancer incidences may be relatively limited. Since skin aging in ordinary people may be predominantly caused by the intrinsic factor, and SS is predominantly caused by intense ultraviolet (UV) B rays, the need of using broadspectrum sunscreens or organic sunscreen ingredients for protection against UVA may need to be re-considered.
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