非hiv和非移植住院患者中新型隐球菌的分离

Yun Xi, P. Zhao, L. Tao, Jing Huang, Youming Chen, Yongmei Fu, Hengbiao Sun, Xuan-Wang You, G. Xiao
{"title":"非hiv和非移植住院患者中新型隐球菌的分离","authors":"Yun Xi, P. Zhao, L. Tao, Jing Huang, Youming Chen, Yongmei Fu, Hengbiao Sun, Xuan-Wang You, G. Xiao","doi":"10.30564/JAMS.V1I2.36","DOIUrl":null,"url":null,"abstract":"A retrospective cross-sectional study for patients with confirmed Cryptococcus neoformans meningitis (CM) in non-HIV-infected and non-transplant hosts in two class-A tertiary hospitals in Guangzhou, China is reported. 181 CM patients were enrolled during the study period, 48% (87/181) of which died. Underlying diseases were risk factor associated with higher mortality, among which diabetes mellitus ranked first for the incidence of CM. The mortality was not related to antifungal drug susceptibility. All strains were considered susceptible to amphotericin B, although interpretative breakpoints for amphotericin B have not yet been established. According to the CLSI guidelines, most of the strains in our study were susceptible to voriconazole, fluconazole, fluorocytosine and dose-dependently susceptible to itraconazle.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"16 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Isolates of Cryptococcus Neoformans from Non-HIV and Non-Transplant Hospitalized Patients\",\"authors\":\"Yun Xi, P. Zhao, L. Tao, Jing Huang, Youming Chen, Yongmei Fu, Hengbiao Sun, Xuan-Wang You, G. Xiao\",\"doi\":\"10.30564/JAMS.V1I2.36\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A retrospective cross-sectional study for patients with confirmed Cryptococcus neoformans meningitis (CM) in non-HIV-infected and non-transplant hosts in two class-A tertiary hospitals in Guangzhou, China is reported. 181 CM patients were enrolled during the study period, 48% (87/181) of which died. Underlying diseases were risk factor associated with higher mortality, among which diabetes mellitus ranked first for the incidence of CM. The mortality was not related to antifungal drug susceptibility. All strains were considered susceptible to amphotericin B, although interpretative breakpoints for amphotericin B have not yet been established. According to the CLSI guidelines, most of the strains in our study were susceptible to voriconazole, fluconazole, fluorocytosine and dose-dependently susceptible to itraconazle.\",\"PeriodicalId\":14958,\"journal\":{\"name\":\"Journal of Advances in Medicine Science\",\"volume\":\"16 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Advances in Medicine Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.30564/JAMS.V1I2.36\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advances in Medicine Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30564/JAMS.V1I2.36","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

本文报道了广州两所三级甲等医院非hiv感染和非移植宿主确诊的新型隐球菌脑膜炎(CM)患者的回顾性横断面研究。研究期间共纳入181例CM患者,其中48%(87/181)死亡。基础疾病是死亡率较高的危险因素,其中糖尿病是CM发病率最高的危险因素。死亡率与抗真菌药物敏感性无关。所有菌株都被认为对两性霉素B敏感,尽管两性霉素B的解释性断点尚未建立。根据CLSI指南,本研究大部分菌株对伏立康唑、氟康唑、氟胞嘧啶敏感,对伊曲康唑剂量依赖敏感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isolates of Cryptococcus Neoformans from Non-HIV and Non-Transplant Hospitalized Patients
A retrospective cross-sectional study for patients with confirmed Cryptococcus neoformans meningitis (CM) in non-HIV-infected and non-transplant hosts in two class-A tertiary hospitals in Guangzhou, China is reported. 181 CM patients were enrolled during the study period, 48% (87/181) of which died. Underlying diseases were risk factor associated with higher mortality, among which diabetes mellitus ranked first for the incidence of CM. The mortality was not related to antifungal drug susceptibility. All strains were considered susceptible to amphotericin B, although interpretative breakpoints for amphotericin B have not yet been established. According to the CLSI guidelines, most of the strains in our study were susceptible to voriconazole, fluconazole, fluorocytosine and dose-dependently susceptible to itraconazle.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信