溶液核磁共振揭示的gpcr功能相关构象动力学

Nihon Kessho Gakkai shi Pub Date : 2022-12-15 DOI:10.5940/jcrsj.64.279

Takumi Ueda, Yutaka Kofuku, K. Takeuchi, Shunsuke Imai, Yutaro Shiraishi, I. Shimada

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引用次数: 0

摘要

核磁共振方法在接近生理温度的水介质中提供了关于GPCR在宽频率范围内的构象动力学的信息，并且对野生型GPCR共价结构进行了最小的修改。本文综述了β 2肾上腺素能受体、μ阿片受体等GPCRs功能相关构象动力学的溶液核磁共振研究进展

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Function-Related Conformational Dynamics of GPCRs Revealed by Solution NMR

NMR methods provide information about conformational dynamics of GPCRs over a wide range of frequencies in aqueous media at near-physiological temperature, with minimal modification of the wild-type GPCR covalent structures. Here we review our solution NMR studies of the function-related conformational dynamics of GPCRs, including β 2 adrenergic receptor, μ opioid receptor

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Nihon Kessho Gakkai shi

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