竖脊神经阻滞治疗肋骨骨折:回顾性倾向匹配队列研究方案

IF 0.1 Q4 ANESTHESIOLOGY
B. Riley, U. Malla, N. Snels, A. Mitchell, C. Abi-Fares, W. Basson, C. Anstey, L. White
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引用次数: 3

摘要

简介:肋骨骨折是最常见的胸椎钝性外伤,占所有胸椎钝性外伤的55%。它们是住院的常见原因,并与显著的发病率和死亡率相关。肋骨骨折并发症导致合并症和死亡率的直接原因包括气胸、血胸、肺挫伤、连枷胸和急性呼吸窘迫综合征;而更多的延迟性并发症包括肺不张、肺炎、肺栓塞、肺气肿和呼吸衰竭。肋骨骨折数量越多,肺部发病率和死亡率越高。延迟并发症的一个基本因素是骨折疼痛继发的通气不足,因此,预防骨折后并发症的一个关键因素是最佳镇痛。几种与阿片类药物全身性镇痛相关的神经轴和区域技术已被描述,证据水平不一。其中一种策略是使用竖屏模块(ESB)。这种技术从来没有被描述过与任何其他技术的关系。本研究的目的是将ESB与全身性阿片类镇痛进行比较,假设接受竖脊肌阻滞的患者呼吸系统并发症发生率较低,因此住院时间较短,死亡率降低。方法与分析:采用倾向匹配的回顾性队列研究。对阳光海岸医院和健康服务中心(SCHHS)急性疼痛服务中心(APS)治疗的肋骨骨折患者进行回顾性分析。每位患者入院时的电子医疗记录(EMR)将被审查,包括年龄、肋骨骨折数量、连击节段的存在、入院时的合并症、使用的管理(单独口服药物vs氯胺酮输注vs患者自控镇痛vs局部并发症(血胸/气胸、肺炎、肺栓塞、呼吸衰竭、需要呼吸支持或ICU、呼吸支持天数、区域阻滞失败(局部麻醉相关的不良反应)、住院时间、出院目的地和住院期间的死亡率。伦理与传播:研究方案和数据收集的伦理批准已批准LNR/2018/QPCH/45155)。研究结果将在同行评议的期刊上发表。结论:目前尚无文献支持ESB优于其他镇痛药,该队列研究将提供初步探索性结果,以指导进一步的随机对照试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Erector Spinae Nerve Block for the Management of Rib Fractures: A Retrospective Propensity Matched Cohort Study Protocol
Introduction: Rib fractures are the most common thoracic blunt trauma injury and constitute up to 55% of all thoracic blunt trauma injuries. They are a common cause of hospital admission and are associated with significant morbidity and mortality. Immediate causes of comorbidities and mortality that stem from complications of rib fractures include pneumothorax, haemothorax, pulmonary contusions, flail chest and acute respiratory distress syndrome; whilst more delayed complications include atelectasis, pneumonia, pulmonary embolism, empyema and respiratory failure. The higher the number of rib fractures, the higher the incidence of pulmonary morbidity and mortality. A fundamental contributor to delayed complications is hypoventilation secondary to pain from the facture(s) and thus, a key element in the prevention of post-fracture complications is optimal analgesia. Several neuraxial and regional techniques have been described in relation to systemic opioid analgesia with varying levels of evidence. One such strategy is the use of the Erector Spinae Block (ESB). This technique has never been described in relation to any other technique. The aim of this study will be to compare the ESB to systemic opioid analgesia with the hypothesis that patients receiving Erector Spinae Blocks will have a lower incidence of respiratory complications and thus a shorter length of stay in hospital and reduced mortality rates. Methods and Analysis: A retrospective cohort study with propensity matching will be performed. A retrospective analysis of patients with rib fractures managed by the Sunshine Coast Hospital and Health Service (SCHHS) Acute Pain Service (APS). Each patient’s electronic medical record (EMR) from their hospital admission will be reviewed for age, number of rib fractures, presence of a flail segment, comorbidities at the time of admission, management used (oral medications alone vs. ketamine infusion vs. patient controlled analgesia vs. regional complications (haemothorax/pneumothorax, pneumonia, pulmonary embolism, respiratory failure, requirement ventilatory support or ICU, number of days of ventilatory support, regional block failure or local anaesthetic related adverse effects), length of stay, discharge destination and mortality during admission. Ethics and Dissemination: Ethics approval for the study protocol and data collection has been approved LNR/2018/QPCH/45155). The study findings will be submitted for publication in a peer reviewed journal. Conclusion: There is currently no available literature to support the use of an ESB over other analgesic this cohort study will provide initial exploratory results to guide further randomised controlled trials.
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