{"title":"三环杂环螺旋呋喃的合成、表征及其对G-292细胞株的细胞毒性评价","authors":"Mona Besharat, Samira Arab-Salmanabadi, O. Moradi","doi":"10.22075/CHEM.2020.20581.1855","DOIUrl":null,"url":null,"abstract":"Synthesis and study of the medicinal properties of new spiro compounds with various functional groups is of great interest to organic and pharmaceutical researchers because of their special structure and conformation. Multi-component reactions are one of the most popular methods for synthesis of these compounds. In this study, the three-component reaction between butyl amine, dimethyl acetylene carboxylate, and 1H-indene-1,2,3-trione in toluene reflux conditions, is described. The three rings heterocyclic Spiro furan was successfully synthesized and characterized by FTIR, 1H-NMR, 13C-NMR, and Mass spectrometry. Then during the cytotoxic studies, its anticancer properties were performed on the G-292 cancer cell lines via the MTT assay and the results were reasonable.","PeriodicalId":7954,"journal":{"name":"Applied Chemistry","volume":"15 1","pages":"25-36"},"PeriodicalIF":0.0000,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Characterization of a Three Rings Heterocyclic Spiro Furan and Evaluation of its Cytotoxicity Properties on G-292 Cell Lines\",\"authors\":\"Mona Besharat, Samira Arab-Salmanabadi, O. Moradi\",\"doi\":\"10.22075/CHEM.2020.20581.1855\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Synthesis and study of the medicinal properties of new spiro compounds with various functional groups is of great interest to organic and pharmaceutical researchers because of their special structure and conformation. Multi-component reactions are one of the most popular methods for synthesis of these compounds. In this study, the three-component reaction between butyl amine, dimethyl acetylene carboxylate, and 1H-indene-1,2,3-trione in toluene reflux conditions, is described. The three rings heterocyclic Spiro furan was successfully synthesized and characterized by FTIR, 1H-NMR, 13C-NMR, and Mass spectrometry. Then during the cytotoxic studies, its anticancer properties were performed on the G-292 cancer cell lines via the MTT assay and the results were reasonable.\",\"PeriodicalId\":7954,\"journal\":{\"name\":\"Applied Chemistry\",\"volume\":\"15 1\",\"pages\":\"25-36\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22075/CHEM.2020.20581.1855\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22075/CHEM.2020.20581.1855","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and Characterization of a Three Rings Heterocyclic Spiro Furan and Evaluation of its Cytotoxicity Properties on G-292 Cell Lines
Synthesis and study of the medicinal properties of new spiro compounds with various functional groups is of great interest to organic and pharmaceutical researchers because of their special structure and conformation. Multi-component reactions are one of the most popular methods for synthesis of these compounds. In this study, the three-component reaction between butyl amine, dimethyl acetylene carboxylate, and 1H-indene-1,2,3-trione in toluene reflux conditions, is described. The three rings heterocyclic Spiro furan was successfully synthesized and characterized by FTIR, 1H-NMR, 13C-NMR, and Mass spectrometry. Then during the cytotoxic studies, its anticancer properties were performed on the G-292 cancer cell lines via the MTT assay and the results were reasonable.
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