观音肽信号传导:观音酸环化酶C依赖和独立信号通路的见解

Journal of cellular signaling Pub Date : 2021-12-31 DOI:10.33696/signaling.2.059

Ivan Strinić, Nikola Habek, Aleksandra Dugandžić

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引用次数: 0

摘要

观音肽(gp)、观音肽(GN)和尿观音肽(UGN)属于尿钠肽(NPs)家族，包括心钠肽(ANP)、脑钠肽(BNP)和c型利钠肽(CNP)。NPs激活膜鸟苷酸环化酶(GC)，也称为颗粒GCs，并导致其第二信使环鸟苷单磷酸(cGMP)的产生，其作用于cGMP依赖性蛋白激酶(PKG)， cGMP调节的磷酸二酯酶(PDE)和cGMP门控通道。

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Guanylin Peptides Signaling: Insights into Guanylate Cyclase C Dependent and Independent Signaling Pathways

Guanylin peptides (GPs), guanylin (GN) and uroguanylin (UGN) belong to the family of natriuretic peptides (NPs), which includes atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). NPs activate membrane guanylate cyclases (GC), also called particulate GCs, and lead to the production of their second messenger cyclic guanosine monophosphate (cGMP), which acts on cGMP dependent protein kinases (PKG), cGMPregulated phosphodiesterases (PDE) and cGMP–gated channels.

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Journal of cellular signaling

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