糖尿病肾病患者的眼部血流动力学特征

中国实用眼科杂志 Pub Date : 2017-08-10 DOI:10.3760/CMA.J.ISSN.1006-4443.2017.08.004

Li Gao

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引用次数: 0

摘要

目的观察2型糖尿病肾病患者眼部血流动力学变化及其与尿白蛋白排泄比的关系，探讨眼部微血管病变与糖尿病肾病的相关性。方法168例住院2型糖尿病患者按尿白蛋白排泄比分为正常尿白蛋白组(63例)、微量尿白蛋白组(60例)和蛋白尿组(45例)，并选择健康体检者30例作为对照组。采用彩色多普勒血流显像定量测定对照组和所有糖尿病患者眼动脉(OA)、睫状体后动脉(PCA)的收缩峰值速度(PSV)、舒张末速度(EDV)和阻力指数(RI)。采用统计学软件对血流动力学参数进行分析。结果与对照组比较，糖尿病患者OA、PCA的PSV、EDV降低，RI升高(P <0.05)。微量白蛋白尿组和蛋白尿组OA、PCA的PSV、EDV均低于无蛋白尿组，RI升高(P <0.05)。蛋白尿组OA、PCA的EDV低于微量白蛋白尿组，RI升高(P <0.05)。UAER与OA、PCA的RI呈正相关(r=0.521、0.642、0.625;P <0.01)与糖尿病患者的EDV呈负相关(r=-0.628，-0.637, P <0.01)。结论眼球血流动力学随糖尿病肾病的病理进展而恶化，提示糖尿病脉络膜病变与糖尿病肾病存在相关性。关键词:眼动脉;糖尿病肾病;彩色多普勒血流成像;血液动力学

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Ocular hemodynamics characteristics in patients with diabetic nephropathy

Objective To investigate the change of ocular hemodynamics and its relationship with urine albumin excretion ratio in patients with type 2 diabetic nephropathy and to discuss the correlation of ocular microangiopathy with diabetic nephropathy. Methods A total of 168 hospitalized patients with type 2 diabetes were divided into three groups according to urine albumin excretion ratio: normal albumin-uria group (n=63), microalbuminuria group (n=60) and proteinuria group (n=45), and 30 cases of healthy physical examination were chosen as control group. Color Doppler flow imaging was used to quantitate peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance index (RI) of the ophthalmic artery (OA), the posterior ciliary artery (PCA) in the control group and all diabetic patients. Statistic software was used to analyze the hemodynamic parameters. Results Compared with the control group, PSV, EDV of OA and PCA were decreased and RI were increased in diabetic patients (P <0.05). PSV, EDV of OA and PCA were decreased and RI were increased in microalbuminuria group and protein-uria group than no proteinuria group (P <0.05). EDV of OA and PCA were decreased and RI were increased in proteinuria group than microalbuminuria group (P <0.05). UAER were positively correlated with RI of OA and PCA (r=0.521, 0.642, 0.625; P <0.01) and negatively correlated EDV in diabetic patients (r=-0.628,-0.637, P <0.01). Conclusions The ocular hemodynamics is aggravating with the pathological progress of diabetic nephropathy, suggesting the correlation between diabetic choroidopathy and diabetic nephropathy. Key words: Ophthalmic artery; Diabetic nephropathy; Color Doppler flow imaging; Hemodynamics

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中国实用眼科杂志

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期刊介绍： China Practical Ophthalmology was founded in May 1983. It is supervised by the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association and China Medical University, and publicly distributed at home and abroad. It is a national-level excellent core academic journal of comprehensive ophthalmology and a series of journals of the Chinese Medical Association. China Practical Ophthalmology aims to guide and improve the theoretical level and actual clinical diagnosis and treatment ability of frontline ophthalmologists in my country. It is characterized by close integration with clinical practice, and timely publishes academic articles and scientific research results with high practical value to clinicians, so that readers can understand and use them, improve the theoretical level and diagnosis and treatment ability of ophthalmologists, help and support their innovative development, and is deeply welcomed and loved by ophthalmologists and readers.