熨平 KRAS 驱动的癌症

IF 0.7 2区哲学 0 RELIGION

Welt des Islams Pub Date : 2022-04-04 Epub Date: 2022-03-09 DOI:10.1084/jem.20212166

Guang Lei, Boyi Gan

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引用次数: 0

摘要

如何特异性地靶向致癌 KRAS 驱动的癌症，同时保护正常组织，仍然是癌症治疗中尚未满足的需求。在本期 JEM 杂志上，Jiang 等人（2022 年，J. Exp. Med.https://doi.org/10.1084/jem.20210739）利用 KRAS 诱导的癌细胞铁瘾，设计了一种巧妙的给药方法，能够选择性地抑制突变 KRAS 肿瘤中的 KRAS 信号，而不抑制正常组织中的 KRAS 信号，为治疗这种基本上无法治愈的疾病提供了一种新策略。

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Iron out KRAS-driven cancer.

How to specifically target oncogenic KRAS-driven cancers while sparing normal tissues remains an unmet need in cancer therapy. In this issue of JEM, Jiang et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20210739) leveraged KRAS-induced iron addiction in cancer cells to design a clever drug delivery approach to enable selective inhibition of KRAS signaling in mutant KRAS tumors but not in normal tissues, offering a new strategy for treating this largely incurable disease.

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来源期刊

Welt des Islams RELIGION-

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： Die Welt des Islams focuses on the history and culture of the people of Islam from the end of the eighteenth century until present times. Special attention is given to literature from this period. Over the last 40 years, Die Welt des Islams has established itself as a journal unrivalled by any other in its field. Its presence in both the major research libraries of the world and in the private libraries of professors, scholars and students shows this journal to be an easy way of staying on top of your discipline. Boasting a large international circulation, Die Welt des Islams takes care to supply its readers with articles in English, French and German.