偏头痛的病因和治疗

Angela A. Stanton
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引用次数: 4

摘要

背景:研究表明,偏头痛患者的大脑有过度活跃的感觉器官和多个感觉受体连接。这些器官的过度活动需要额外的营养供应来支持增加的电活动。今天的药物通过阻断必需的电压依赖性钙或钠通道而不是提供营养来减少或阻止这些神经元的功能。我们的问题是:如果我们为偏头痛患者额外的脑电活动提供支持,它会在不使用药物的情况下预防偏头痛吗?方法:我们回顾了已发表的文献,并对Facebook偏头痛研究小组中的650名志愿者进行了为期6个月的研究。研究人员筛选了参与者的偏头痛类型,并回答了一份关于医疗状况、使用药物和生活方式的问卷。他们被告知如何使用偏头痛治疗方案,并每周接受一次评估。研究发现:富含碳水化合物和缺乏盐和水的饮食会加重偏头痛的发生频率,阻断电压门控钙或钠通道的药物可能会加重偏头痛的发生频率。停止这些药物,减少碳水化合物和增加电解质中的生理盐水似乎可以预防和/或停止偏头痛。结论:由葡萄糖、电解质矿物质(Na, Cl-, K)比例引起的细胞水和钠的外排可能在碳水化合物重的饮食中被破坏,导致偏头痛。改变饮食,包括增加盐摄入量和减少碳水化合物摄入量,似乎可以防止葡萄糖引起的电解质变化,从而减少偏头痛的发生频率。在目前的研究中,所有做出这些饮食改变的参与者都能够消除偏头痛药物并保持无偏头痛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Migraine Cause and Treatment
Background: Research shows that migraine brains have hyperactive sensory organs and multiple sensory receptor connections. Hyper activity of these organs needs extra supply of nutrition to support increased electrical activity. Today’s medicines reduce or prevent the functioning of these neurons by blocking essential voltage dependent calcium or sodium channel instead of providing nutrients. We asked: if we provide support for extra electrical activity of migraineurs, would it prevent migraines without the use of medicines?Methods: We reviewed published literature and conducted research over 6 months studying 650 volunteer migraineurs in a migraine-research Facebook group. Participants were screened for migraine types, answered a questionnaire on medical conditions, medicines used, and lifestyle. They were provided instructions on the use of the migraine protocol and were evaluated weekly.Findings: Migraine frequency appears to be exacerbated by carbohydrate-rich and salt- and water-poor diets and may be worsened by medicines that block voltage gated calcium or sodium channels. Stopping these medicines, reducing carbohydrates and increasing saline in electrolytes appears to prevent and/or stop migraines.Conclusions: H2O and Na efflux from cells caused by glucose, electrolyte mineral (Na , Cl-, K ) ratio may be disrupted in carbohydrate heavy diets causing migraines. Changes to diet that include increased salt intake along with reduced carbohydrate intake appears to prevent glucose induced electrolyte changes which then decreases migraine frequency. In the present study, all participants who made these dietary changes were able to eliminate migraine medications and remained migraine free.
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