血管紧张素-(1-7)在心血管疾病治疗中的应用前景

C. Höcht, M. Mayer, C. Taira
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引用次数: 6

摘要

在过去的十年中,肾素-血管紧张素系统的新的生物活性成分被发现。血管紧张素-(1-7)(Ang-(1-7))是血管紧张素I和血管紧张素II (Ang II)的代谢物,被认为是肾素-血管紧张素系统中最多元的成分,作为Ang II的反调节介质。Ang-(1-7)对心血管系统有有益的作用,包括降低血压、心肌抗肥厚和抗纤维化作用、逆转肾功能障碍等。最近发现的与Ang-(1-7)合成有关的酶途径,如血管紧张素转换酶-2 (ACE2)和这种七肽的特异性受体Mas受体的存在,增加了人们对设计旨在提高Ang-(1-7)生物作用的治疗策略的兴趣。ACE抑制剂、AT1受体阻滞剂和醛固酮拮抗剂通过不同机制提高Ang-(1-7)水平。事实上,非肽类Ang-(1-7)激动剂和ACE2激活剂正在开发中,可能在心血管疾病的治疗中发挥作用。本综述的目的是描述Ang-(1-7)的生化和生理作用,旨在提高Ang-(1-7)活性的治疗策略,重点是它们在心血管疾病治疗中的可能作用和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic Perspectives of Angiotensin-(1-7) in the Treatment of Cardiovascular Disease
In the last decade, new biologically active components of the renin-angiotensin system were found. Angiotensin-(1-7) (Ang-(1-7)), a metabolite of angiotensin I and angiotensin II (Ang II), is considered the most pleiotropic component of the renin-angiotensin system, acting as a counterregulatory mediator of Ang II. Ang-(1-7) exerts beneficial effects on the cardiovascular system, including reduction of blood pressure, myocardial antihypertrofic and antifibrotic actions, and reversal of renal dysfunction, among others. Recent discovery of enzymatic pathways involved in Ang-(1-7) synthesis, such as the angiotensin-converting enzyme-2 (ACE2) and the existence of a specific receptor to this heptapeptide, the Mas receptor, have increased interest in the design of therapeutic strategies aimed at increasing the biological actions of Ang-(1-7). ACE inhibitors, AT1 receptor blockers and aldosterone antagonists enhance Ang-(1-7) levels by different mechanisms. Actually, non-peptidic Ang-(1-7) agonists and ACE2 activators are under development and could have a role in the treatment of cardiovascular diseases. The aim of the present review is to describe the biochemical and physiological actions of Ang-(1-7), the therapeutic strategies designed to enhance Ang-(1-7) activity foccusing in their possible role and limitations in the treatment of cardiovascular disease.
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