性激素缺乏对肩袖修复发生率的影响

Karch M. Smith, J. Hotaling, A. Presson, Chong Zhang, J. Horns, L. Cannon-Albright, C. Teerlink, R. Tashjian, P. Chalmers
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引用次数: 4

摘要

背景:本研究的目的是分析性激素缺乏与肩袖修复(RCR)之间的关系,并使用来自美国大型保险数据库的数据。方法:对Truven Health MarketScan数据库中的参保对象进行回顾性分析,收集RCR病例和数据库中年龄、性别和年龄相匹配的对照组的数据。采用校正匹配变量的多变量logistic回归模型比较RCR状态与雌激素缺乏状态和睾酮缺乏状态的差异。使用退伍军人家谱项目数据库的数据证实了这些关联,该数据库估计了有性激素缺乏症和无性激素缺乏症患者发生RCR的相对风险。结果:女性雌激素缺乏症患者RCR发生率高48%(优势比,1.48;95%置信区间为1.44 ~ 1.51;P < 0.001)。男性睾酮缺乏的RCR几率高出89%(优势比,1.89;95%置信区间为1.82 ~ 1.96;P < 0.001)。在退伍军人家谱项目数据库中,RCR患者雌激素缺乏的相对风险为2.58(95%可信区间,2.15 ~ 3.06;P < 0.001),睾酮缺乏的相对危险度为3.05(95%可信区间2.67 ~ 3.47;P < 0.001)。结论:性激素缺乏与RCR显著相关。未来的前瞻性研究将有必要了解肩袖疾病的病理生理学,因为它与性激素有关。证据等级:预后IV级。参见《作者说明》获得证据等级的完整描述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Sex Hormone Deficiency on the Incidence of Rotator Cuff Repair
Background: The purpose of the present study was to analyze the association between sex hormone deficiency and rotator cuff repair (RCR) with use of data from a large United States insurance database. Methods: A retrospective analysis of insured subjects from the Truven Health MarketScan database was conducted, collecting data for RCR cases as well as controls matched for age, sex, and years in the database. Multivariable logistic regression models adjusted for matching variables were utilized to compare RCR status with estrogen deficiency status and testosterone deficiency status. These associations were confirmed with use of data from the Veterans Genealogy Project database, with which the relative risk of RCR was estimated for patients with and without sex hormone deficiency. Results: The odds of RCR for female patients with estrogen deficiency were 48% higher (odds ratio, 1.48; 95% confidence interval, 1.44 to 1.51; p < 0.001) than for those without estrogen deficiency. The odds of RCR for males with testosterone deficiency were 89% higher (odds ratio, 1.89; 95% confidence interval, 1.82 to 1.96; p < 0.001) than for those without testosterone deficiency. Within the Veterans Genealogy Project database, the relative risk of estrogen deficiency among RCR patients was 2.58 (95% confidence interval, 2.15 to 3.06; p < 0.001) and the relative risk of testosterone deficiency was 3.05 (95% confidence interval, 2.67 to 3.47; p < 0.001). Conclusions: Sex hormone deficiency was significantly associated with RCR. Future prospective studies will be necessary to understand the pathophysiology of rotator cuff disease as it relates to sex hormones. Level of Evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
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