COVID-19住院患者抗生素使用频率的回顾性分析

IF 0.2 Q4 ANESTHESIOLOGY
S. Dubrov, Y. Zaikin, S. Cherniaiev, T. Baranovska, M. Denysiuk, S. O. Sereda
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引用次数: 0

摘要

介绍。在乌克兰和其他国家的医疗机构中,大多数COVID-19住院患者都不合理地使用抗菌药物,尽管许多科学研究证明,COVID-19患者的继发性细菌感染极为罕见(住院患者中从3%到10%)。工作的目标。对基辅市两家医疗机构COVID-19住院患者抗菌药物的使用频率和处方合理性进行回顾性分析。材料和方法。对一名随机选择的住院患者(003 / y表)的240份医疗记录进行回顾性研究,该患者于2020年9月至2021年4月期间因诊断为COVID-19而住院,并在基辅市的两个社区医疗机构住院。结果和讨论。在CUE KCCH№17中,接受抗菌药物治疗的患者人数(抗菌药物由医师开具,只有在合理怀疑或确认细菌感染时才开具)为120例中的20例(16.7%),而在比较机构中,抗菌药物的处方频率占120例分析病例中的117例(97.5%)。两家比较机构患者住院治疗的平均时间无统计学差异,CUE KCCH№17患者住院治疗的平均时间为11.2±6.0天,对照组患者住院治疗的平均时间为12.3±4.6天(p < 0.05)。两家医院治疗的患者死亡率无差异。通过对研究结果的分析,可以得出结论,无指征的常规处方抗菌药物不能提高COVID-19患者的治疗质量,不能缩短住院时间和死亡率,不能预防住院患者继发细菌感染的风险。然而,它导致治疗一个病例的成本显著增加,并导致医院微生物对抗菌药物的耐药性增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A RETROSPECTIVE ANALYSIS OF THE FREQUENCY OF ANTIBIOTIC USE IN HOSPITALIZED PATIENTS WITH COVID-19
Introduction. Most hospitalized patients with COVID-19, both in medical institutions in Ukraine and in other countries, are unreasonably receiving antibacterial drugs, despite the fact that secondary bacterial infections in patients with COVID-19 are extremely rare, as evi-denced by numerous scientific studies (from 3 up to 10% among hospitalized patients).The goal of the work. Conduct a retrospective analysis of the frequency of use and justification of the prescription of antibacterial drugs in hospitalized patients with COVID-19 in two medical institutions in the city of Kyiv.Materials and methods. A retrospective study of 240 medical records of an inpatient (form 003 / y), randomly selected, hospitalized with a diagnosis of COVID-19 from September 2020 to April 2021, who were hospitalized in two communal medical institutions in the city of Kyiv.Results and discussion. The number of patients who received antibacterial drugs in the CUE KCCH №17 (antibacterial drugs were prescribed by concilium and only if there was a reasonable suspicion or confirmation of a bacterial infection) was 20 out of 120 (16.7%), while in the compared institution the frequency of prescription of antibacterial drugs accounted for 117 patients out of 120 analyzed cases (97.5%). The average length of stay of a patient on inpatient treatment in the two compared institutions had no statistically significant differences and was 11.2 ± 6.0 days in patients with the CUE KCCH №17, and 12.3 ± 4.6 days in patients from the control institution (р>0.05). The mortality rate did not differ between patients treated in both hospitals.Conclusions. After analyzing the results of the study, it can be concluded that the routine prescription of antibacterial drugs without available indications does not have the advantage of improving the quality of treatment for patients with COVID-19, does not reduce the duration of inpatient treatment and the mortality rate, does not prevent the risk of secondary bacterial infection in hospitalized patients. however, it leads to a significant increase in the cost of treating a case of the disease and leads to an increase in the resistance of hospital microorganisms to antibacterial drugs.
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