非洲爪蟾EXT1 cDNA的系统发育分析

DNA Sequence Pub Date : 2002-01-01 DOI:10.1080/10425170290029990

A. Hill, N. Brown, M. S. Hill, D. Wells

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引用次数: 0

摘要

EXT家族基因参与了对发育至关重要的硫酸肝素分子的生物合成。EXT家族的成员在果蝇的原肠胚形成、翅膀形成和脊椎动物的骨骼发育中发挥了重要作用。EXT家族成员已从几个系统发育不同的物种中分离出来。本文报道了非洲爪蟾EXT1家族首个成员的分离，并讨论了该基因家族的进化起源。

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Identification of the Xenopus laevis cDNA for EXT1: A Phylogenetic Perspective

The EXT family of genes is involved in the developmentally important biosynthesis of heparan sulfate molecules. Members of the EXT family have a demonstrated role in gastrulation, wing formation in flies, and proper bone development in vertebrates. EXT family members have been isolated from several phylogenetically diverse species. We report here, the isolation of the first Xenopus laevis EXT1 family member and discuss the evolutionary origins of this gene family.

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DNA Sequence

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