杀菌剂对大鼠肝肾组织元素组成的影响

S. Khyzhnyak, A. O. Velinskaya, E. V. Byschuk, V. Voitsitskiy
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摘要

杀菌剂在人类生活各个领域的广泛使用对人类和环境都造成了负面影响。本文报道了化学类三唑类系统杀菌剂对大鼠肾和肝组织中宏量元素和微量元素含量的急性影响的研究结果。采用电感耦合等离子体原子发射光谱法测定化学元素的含量。大鼠肝脏和肾脏中宏量元素和微量元素含量的变化表明了杀真菌作用的组织特异性。在含戊康唑杀菌剂用量为250 g/dm3或含戊康唑杀菌剂用量为125 g/dm3 +三唑美丰、100 g/dm3的复合杀菌剂作用下,肝脏中钾(K)、钙(Ca)、铬(Cr)、铁(Fe)、铜(Cu)、锌(Zn)含量显著升高(P<0.05)。这会导致器官的功能负荷。相反,在肾脏中,杀菌剂导致微量元素(Zn、Mn、Cr)含量降低(P<0.05),锌铜比降低(P<0.05),铁含量增加(P<0.05),这可能表明器官氧化代谢紊乱,但Ca含量增加(P<0.05) -表征细胞膜的通透性。检测到的肾和肝组织中宏微量元素含量的变化可能是细胞内控制和效应信号的功能障碍和有效性的改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Elemental composition of liver and kidney tissues of rats under the influence of fungicides
Widespread use of fungicides in various spheres of human life leads to negative consequences for both humans and the environment. The article presents the results of a study of the acute effect of systemic fungicides of the chemical class triazoles on the content of macro- and microelements in kidney and liver rat tissues. The content of chemical elements was determined by inductively coupled plasma atomic emission spectrometry. The established changes in the content of macro- and microelements in the rat liver and kidney indicate tissue specificity of the fungicidal action. Under the influence of fungicide containing tebuconazole in amount of 250 g/dm3 or combined fungicide containing (tebuconazole, 125 g/dm3 + triadimefon, 100 g/dm3) the content of Potassium (K), Calcium (Ca), Chromium (Cr), Iron (Fe), Copper (Cu) and Zinc (Zn) increased sugnificantly (P<0.05) in liver. This can lead to a functional load on the organ. Contrary, in kidney the studied fungicides cause the decrease (P<0.05) in the content of trace elements (Zn, Mn, Cr), Zn:Cu ratio and increase in the Fe content, which may indicate the oxidative metabolic disorders in the organ, but an increase in the Ca content (P<0.05) — characterize the permeability of cell membranes. The detected changes in the content of macro- and microelements in the kidney and liver tissues may be the dysfunction and altering the effectiveness of intracellular control and effector signals.
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