F. Lakbakbi el Yaagoubi , H. Charoute , A. Bakhchane , M. Ajjemami , H. Benrahma , A. Errouagui , M. Kandil , H. Rouba , A. Barakat
{"title":"摩洛哥APOA5 rs662799和rs3135506多态性与肥胖的关联分析","authors":"F. Lakbakbi el Yaagoubi , H. Charoute , A. Bakhchane , M. Ajjemami , H. Benrahma , A. Errouagui , M. Kandil , H. Rouba , A. Barakat","doi":"10.1016/j.patbio.2015.09.002","DOIUrl":null,"url":null,"abstract":"<div><p>The aim of the present study is to explore the association between the <em>APOA5</em> polymorphisms and haplotypes with obesity in Moroccan patients. The study was performed in 459 subjects, Obese (<em>n</em> <!-->=<!--> <!-->164) and non-obese (<em>n</em> <!-->=<!--> <!-->295). All subjects were genotyped for the <em>APOA5</em> -1131T<!--> <!-->><!--> <!-->C (rs662799) and c.56C<!--> <!-->><!--> <!-->G (rs3135506) polymorphisms. The contribution of <em>APOA5</em> polymorphisms and haplotypes in the increased risk of obesity were explored using logistic regression analyses. The -1131T<!--> <!-->><!--> <!-->C and c.56C<!--> <!-->><!--> <!-->G polymorphisms were significantly associated with obesity. Both polymorphisms were strongly associated with increased BMI. Analysis of constructed haplotypes showed a significant association between CG haplotype and susceptibility to obesity (OR [95%CI]<!--> <!-->=<!--> <!-->3.09 [1.93–4.97]; <em>P</em> <!--><<!--> <!-->0.001). These results support a potential role for <em>APOA5</em> common variants and related haplotypes as risk factors for obesity.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2015.09.002","citationCount":"6","resultStr":"{\"title\":\"Association analysis of APOA5 rs662799 and rs3135506 polymorphisms with obesity in Moroccan patients\",\"authors\":\"F. Lakbakbi el Yaagoubi , H. Charoute , A. Bakhchane , M. Ajjemami , H. Benrahma , A. Errouagui , M. Kandil , H. Rouba , A. Barakat\",\"doi\":\"10.1016/j.patbio.2015.09.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The aim of the present study is to explore the association between the <em>APOA5</em> polymorphisms and haplotypes with obesity in Moroccan patients. The study was performed in 459 subjects, Obese (<em>n</em> <!-->=<!--> <!-->164) and non-obese (<em>n</em> <!-->=<!--> <!-->295). All subjects were genotyped for the <em>APOA5</em> -1131T<!--> <!-->><!--> <!-->C (rs662799) and c.56C<!--> <!-->><!--> <!-->G (rs3135506) polymorphisms. The contribution of <em>APOA5</em> polymorphisms and haplotypes in the increased risk of obesity were explored using logistic regression analyses. The -1131T<!--> <!-->><!--> <!-->C and c.56C<!--> <!-->><!--> <!-->G polymorphisms were significantly associated with obesity. Both polymorphisms were strongly associated with increased BMI. Analysis of constructed haplotypes showed a significant association between CG haplotype and susceptibility to obesity (OR [95%CI]<!--> <!-->=<!--> <!-->3.09 [1.93–4.97]; <em>P</em> <!--><<!--> <!-->0.001). These results support a potential role for <em>APOA5</em> common variants and related haplotypes as risk factors for obesity.</p></div>\",\"PeriodicalId\":19743,\"journal\":{\"name\":\"Pathologie-biologie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.patbio.2015.09.002\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pathologie-biologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0369811415000966\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathologie-biologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0369811415000966","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association analysis of APOA5 rs662799 and rs3135506 polymorphisms with obesity in Moroccan patients
The aim of the present study is to explore the association between the APOA5 polymorphisms and haplotypes with obesity in Moroccan patients. The study was performed in 459 subjects, Obese (n = 164) and non-obese (n = 295). All subjects were genotyped for the APOA5 -1131T > C (rs662799) and c.56C > G (rs3135506) polymorphisms. The contribution of APOA5 polymorphisms and haplotypes in the increased risk of obesity were explored using logistic regression analyses. The -1131T > C and c.56C > G polymorphisms were significantly associated with obesity. Both polymorphisms were strongly associated with increased BMI. Analysis of constructed haplotypes showed a significant association between CG haplotype and susceptibility to obesity (OR [95%CI] = 3.09 [1.93–4.97]; P < 0.001). These results support a potential role for APOA5 common variants and related haplotypes as risk factors for obesity.
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