原料药和制剂中拉莫三嗪含量分析方法综述

Rutuja S Nalkar, S. Siddheshwar, M. Kolhe
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引用次数: 0

摘要

拉莫三嗪是一种抗惊厥药物,用于治疗癫痫和双相情感障碍/主要情感障碍(躁狂抑郁症)。拉莫三嗪是苯三嗪类抗癫痫药物。对于癫痫,它用于治疗部分性癫痫发作,原发性和继发性强直阵挛性癫痫发作,以及与lenox - gastuat综合征相关的癫痫发作,这些癫痫发作与其他抗惊厥药的化学性质无关。拉莫三嗪是一种苯基三嗪,副作用相对较少,在单药治疗中不需要血液监测/观察。它还可以作为情绪稳定剂。拉莫三嗪常见的副作用包括恶心、嗜睡、头痛、呕吐、协调困难和皮疹。严重的副作用包括贫血、缺乏红细胞、积累自杀风险、史蒂文斯-约翰逊综合征和过敏。它指出在怀孕或哺乳期间使用拉莫三嗪会导致伤害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review on Analytical Method for Determination of Lamotrigine in Bulk and Pharmaceutical Dosage Form
Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy & bipolar disorder/major affective disorder (manic depression). Lamotrigine is and antiepileptic drug of phenyltriazine class. For epilepsy it is used to treat the partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with the Lennox-Gastuat syndrome and are chemically unrelated to the other anticonvulsants. Lamotrigine is a phenyltriazine that has comparatively few side-effects and it does not requires blood monitoring/observance in monotherapy. It additionally acts as a mood stabilizer. Common side-effects of lamotrigine include, nausea, sleepiness, headache, vomiting, trouble/bother with co-ordination and rash. Serious side-effects include in, lack of red blood cells, accumulated in risk of suicide, Stevens-Johnson syndrome and allergy. It issues that use of lamotrigine throughout pregnancy or breastfeeding it’s going to lead/result in harm/damage.
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