{"title":"咖啡因对骨骼肌细胞内作用部位的定位","authors":"H Huddart, K Oates","doi":"10.1016/0010-406X(70)90526-8","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Exposure of frog and crayfish skeletal muscle to 10 mM caffeine saline results in a rapid dilation of the sarcoplasmic reticular tubules.</p></span></li><li><span>2.</span><span><p>2. Prolonged exposure to caffeine leads to disintegration of the sarcoplasmic reticular membranes, and after 30 min treatment the transverse tubules rupture,' destroying the trids and dyads.</p></span></li><li><span>3.</span><span><p>3. Destruction of triads and dyads releases their bound calcium, causing protracted contractures, and the calcium pump of the sarcoplasmic reticulum is inactivated.</p></span></li><li><span>4.</span><span><p>4. Tension changes in muscles exposed to caffeine closely parallel the damage caused by caffeine to the sub-cellular structures involved in excitation-contraction] coupling.</p></span></li></ul></div>","PeriodicalId":78189,"journal":{"name":"Comparative biochemistry and physiology","volume":"36 4","pages":"Pages 677-678, IN3-IN8, 679-682"},"PeriodicalIF":0.0000,"publicationDate":"1970-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0010-406X(70)90526-8","citationCount":"28","resultStr":"{\"title\":\"Localization of the intracellular site of action of caffeine on skeletal muscle\",\"authors\":\"H Huddart, K Oates\",\"doi\":\"10.1016/0010-406X(70)90526-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. Exposure of frog and crayfish skeletal muscle to 10 mM caffeine saline results in a rapid dilation of the sarcoplasmic reticular tubules.</p></span></li><li><span>2.</span><span><p>2. Prolonged exposure to caffeine leads to disintegration of the sarcoplasmic reticular membranes, and after 30 min treatment the transverse tubules rupture,' destroying the trids and dyads.</p></span></li><li><span>3.</span><span><p>3. Destruction of triads and dyads releases their bound calcium, causing protracted contractures, and the calcium pump of the sarcoplasmic reticulum is inactivated.</p></span></li><li><span>4.</span><span><p>4. Tension changes in muscles exposed to caffeine closely parallel the damage caused by caffeine to the sub-cellular structures involved in excitation-contraction] coupling.</p></span></li></ul></div>\",\"PeriodicalId\":78189,\"journal\":{\"name\":\"Comparative biochemistry and physiology\",\"volume\":\"36 4\",\"pages\":\"Pages 677-678, IN3-IN8, 679-682\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1970-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0010-406X(70)90526-8\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative biochemistry and physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0010406X70905268\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0010406X70905268","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Localization of the intracellular site of action of caffeine on skeletal muscle
1.
1. Exposure of frog and crayfish skeletal muscle to 10 mM caffeine saline results in a rapid dilation of the sarcoplasmic reticular tubules.
2.
2. Prolonged exposure to caffeine leads to disintegration of the sarcoplasmic reticular membranes, and after 30 min treatment the transverse tubules rupture,' destroying the trids and dyads.
3.
3. Destruction of triads and dyads releases their bound calcium, causing protracted contractures, and the calcium pump of the sarcoplasmic reticulum is inactivated.
4.
4. Tension changes in muscles exposed to caffeine closely parallel the damage caused by caffeine to the sub-cellular structures involved in excitation-contraction] coupling.
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