肌萎缩性侧索硬化症的非运动表现为冷漠

Q4 Pharmacology, Toxicology and Pharmaceutics
Anca Moţăţăianu, Ioana Ormenișan, R. Bălaşa
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引用次数: 0

摘要

虽然肌萎缩性侧索硬化症(ALS)一词经常与运动神经元疾病交替使用,但ALS被普遍认为是一种多系统疾病。认知障碍是ALS的一个公认特征,影响语言、记忆和行为,而冷漠被认为是ALS中普遍存在的行为改变。它可以分为三个亚型:执行冷漠、情感冷漠和发起冷漠。在三种亚型中,起始冷漠在ALS患者中很常见。即使在不符合ALS合并额颞叶痴呆标准的患者中,也可以观察到低调的神经精神和认知变化。在一些神经影像学研究中,冷漠也被发现与内侧额叶皮层和皮层下结构的破坏有系统的联系,这些研究证实了这种疾病早期存在的大脑病变。因此,越来越多的证据表明,运动体征和症状伴随甚至先于认知和行为改变,对非运动体征和症状的筛查可能具有临床相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Apathy as Non-Motor Manifestation in Amyotrophic Lateral Sclerosis
Abstract Although the term of amyotrophic lateral sclerosis (ALS) is often used interchangeably with motor neuron disease, ALS is universally accepted as a multisystem disorder. Cognitive impairment is an acknowledged feature of ALS, affecting language, memory and behaviour, and apathy is considered to be the prevalent behavioural alteration in ALS. It can be divided in three subtypes: executive, emotional and initiation apathy. Out of the three subtypes, initiation apathy is common among patients with ALS. Even in patients that do not meet the criteria for ALS with frontotemporal dementia, low-key neuropsychiatric and cognitive changes can be observed. Apathy has also been found to be systematically associated with disruptions in medial frontal cortex and subcortical structures in several neuroimaging studies that confirm the pre-existing brain lesions in the early stages of this disease. Thus, there is a growing body of evidence that motor signs and symptoms are accompanied or even preceded by cognitive and behavioural alterations, and screening for non-motor signs and symptoms can be clinically relevant.
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来源期刊
Acta Marisiensis - Seria Medica
Acta Marisiensis - Seria Medica Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.40
自引率
0.00%
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0
审稿时长
24 weeks
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