{"title":"新型潜在胆固醇吸收抑制剂N-(4-氟苯基)-5-(4-氟苯基)-2-(4-羟基苯基)五胺的首次合成","authors":"J. Guillon, S. Stiebing, M. Robba","doi":"10.1111/J.2042-7158.2000.TB00212.X","DOIUrl":null,"url":null,"abstract":"The first synthesis of N-(4-fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide and a new synthesis of 1-(4-fluorophenyl)-3-[(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone starting from 4-fluorobenzaldehyde are described. This new amide could represent a potential new cholesterol absorption inhibitor.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"1 1","pages":"25-29"},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"First Synthesis of N-(4-Fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide, a New Potential Cholesterol Absorption Inhibitor\",\"authors\":\"J. Guillon, S. Stiebing, M. Robba\",\"doi\":\"10.1111/J.2042-7158.2000.TB00212.X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The first synthesis of N-(4-fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide and a new synthesis of 1-(4-fluorophenyl)-3-[(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone starting from 4-fluorobenzaldehyde are described. This new amide could represent a potential new cholesterol absorption inhibitor.\",\"PeriodicalId\":19946,\"journal\":{\"name\":\"Pharmacy and Pharmacology Communications\",\"volume\":\"1 1\",\"pages\":\"25-29\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacy and Pharmacology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/J.2042-7158.2000.TB00212.X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/J.2042-7158.2000.TB00212.X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
First Synthesis of N-(4-Fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide, a New Potential Cholesterol Absorption Inhibitor
The first synthesis of N-(4-fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide and a new synthesis of 1-(4-fluorophenyl)-3-[(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone starting from 4-fluorobenzaldehyde are described. This new amide could represent a potential new cholesterol absorption inhibitor.
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