DOSE-DEPENDENT CARDIOTROPIC EFFECTS OF ACETYLSALICYLATES

The effect of acetylsalicylic acid and its complex compounds with the metals cobalt (Co2+), zinc (Zn2+), nickel (Ni2+) and manganese (Mn2+) at doses of 5, 10 and 20 mg/kg on the parameters of the rat cardiorespiratory system was studied. It is shown that in the process of complexation of acetylsalicylic acid with bimetals, there is not only an increase or decrease in certain effects inherent in the precursor molecule – acetylsalicylic acid, but also the appearance of new properties, the manifestation of which is dose-dependent. The study was carried out on the basis of the Center for collective use of scientific equipment «Experimental Physiology and Biophysics» of the Department of Human and Animal Physiology and Biophysics of the V. I. Vernadsky Crimean Federal University. The research of the biological effect of the acetylsalicylic acid, АСCo2+, АСZn2+, АСNi2+, АСMn2+was carried out during their intraperitoneal injection into rats in doses of 5, 10 and 20 mg/kg. Simultaneously the following characteristics of all the groups’ animals were registered: heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP) and diastolic blood pressure (DBP). The pulse pressure (PP) was calculated on the basis of the SBP and DBP indices difference. BP, HR and RR of the rats were registered with the help of the system NIBP200A («BiopacSystems, Inc.», USA). The experimental data obtained in our studies confirm the literature data, which show that in the process of complexation there is not only an increase or decrease in certain effects that are characteristic of precursor molecules-salicylates, but also the appearance of new properties of derived substances. This suggests that certain biological effects of salicylates may be associated with interaction with metalloenzymes. Thus, the obtained data confirm the cardiotropic effectiveness of new coordination compounds, show the dose dependence of these effects and open up the prospects for further studies of their biological action when used repeatedly in chronic experiments.