阿米卡星在印度儿科患者中的人群药代动力学

Butchi Raju Akondi, R. Chodavarapu, K. Devarakonda
{"title":"阿米卡星在印度儿科患者中的人群药代动力学","authors":"Butchi Raju Akondi, R. Chodavarapu, K. Devarakonda","doi":"10.1080/10601330802383441","DOIUrl":null,"url":null,"abstract":"The aim of this study was to describe population pharmacokinetics of amikacin in Indian pediatric population. Dosage adjustment based on individual pharmacokinetic parameters is of considerable importance for effective and safe use of drugs. Extensive work on amikacin and other aminoglycosides was carried out in different pediatric patient populations but no data are available in Indian pediatric patients. In the present study 74 steady state concentrations of amikacin were analyzed from 42 patients. Pharmacostatistical work was done by using NONMEM. The covariates evaluated in this study were age, body weight, height, and sex and creatinine clearance. The model found to best describe the data following FO method was: Clearance (CL) = θ1*(wt/14.2)*exp. (η1) and volume (V) = θ2*exp (η2) and following FOCE method was: Clearance (CL) = θ1*(age/5.38) + θ3*(wt/14.2)*exp.(η1) and volume(V) = θ2*exp(η2). The final model estimates of CL and V estimated by FO method were1.02 L/h and 4.55L respectively and by FOCE method were1.07L/hr and 4.91L respectively. These parameters are utilized for individualizing the loading and maintenance doses in pediatric patients.","PeriodicalId":10446,"journal":{"name":"Clinical Research and Regulatory Affairs","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Population Pharmacokinetics of Amikacin in Indian Pediatric Patients\",\"authors\":\"Butchi Raju Akondi, R. Chodavarapu, K. Devarakonda\",\"doi\":\"10.1080/10601330802383441\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of this study was to describe population pharmacokinetics of amikacin in Indian pediatric population. Dosage adjustment based on individual pharmacokinetic parameters is of considerable importance for effective and safe use of drugs. Extensive work on amikacin and other aminoglycosides was carried out in different pediatric patient populations but no data are available in Indian pediatric patients. In the present study 74 steady state concentrations of amikacin were analyzed from 42 patients. Pharmacostatistical work was done by using NONMEM. The covariates evaluated in this study were age, body weight, height, and sex and creatinine clearance. The model found to best describe the data following FO method was: Clearance (CL) = θ1*(wt/14.2)*exp. (η1) and volume (V) = θ2*exp (η2) and following FOCE method was: Clearance (CL) = θ1*(age/5.38) + θ3*(wt/14.2)*exp.(η1) and volume(V) = θ2*exp(η2). The final model estimates of CL and V estimated by FO method were1.02 L/h and 4.55L respectively and by FOCE method were1.07L/hr and 4.91L respectively. These parameters are utilized for individualizing the loading and maintenance doses in pediatric patients.\",\"PeriodicalId\":10446,\"journal\":{\"name\":\"Clinical Research and Regulatory Affairs\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Research and Regulatory Affairs\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/10601330802383441\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Research and Regulatory Affairs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/10601330802383441","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

本研究的目的是描述阿米卡星在印度儿科人群中的群体药代动力学。基于个体药代动力学参数的剂量调整对于药物的有效和安全使用具有相当重要的意义。对阿米卡星和其他氨基糖苷的广泛研究在不同的儿科患者群体中进行,但没有印度儿科患者的数据。本研究分析了42例患者的74例阿米卡星稳态浓度。采用NONMEM进行药物统计工作。本研究评估的协变量包括年龄、体重、身高、性别和肌酐清除率。采用FO方法得到的最能描述数据的模型为:Clearance (CL) = θ1*(wt/14.2)*exp。(η1),体积(V) = θ2*exp(η2),采用的FOCE方法为:清除率(CL) = θ1*(年龄/5.38)+ θ3*(wt/14.2)*exp (η1),体积(V) = θ2*exp(η2)。FO法估算的CL和V最终模型估计值分别为1.02 L/h和4.55L, FOCE法估算的CL和V最终模型估计值分别为1.07L/h和4.91L。这些参数用于个性化儿科患者的负荷和维持剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Population Pharmacokinetics of Amikacin in Indian Pediatric Patients
The aim of this study was to describe population pharmacokinetics of amikacin in Indian pediatric population. Dosage adjustment based on individual pharmacokinetic parameters is of considerable importance for effective and safe use of drugs. Extensive work on amikacin and other aminoglycosides was carried out in different pediatric patient populations but no data are available in Indian pediatric patients. In the present study 74 steady state concentrations of amikacin were analyzed from 42 patients. Pharmacostatistical work was done by using NONMEM. The covariates evaluated in this study were age, body weight, height, and sex and creatinine clearance. The model found to best describe the data following FO method was: Clearance (CL) = θ1*(wt/14.2)*exp. (η1) and volume (V) = θ2*exp (η2) and following FOCE method was: Clearance (CL) = θ1*(age/5.38) + θ3*(wt/14.2)*exp.(η1) and volume(V) = θ2*exp(η2). The final model estimates of CL and V estimated by FO method were1.02 L/h and 4.55L respectively and by FOCE method were1.07L/hr and 4.91L respectively. These parameters are utilized for individualizing the loading and maintenance doses in pediatric patients.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信