前庭偏头痛伴脑干先兆:发病机制、临床类型、流产及预防治疗综述

A. Zhang, Ai-yuan Zhang, L. Gao, Li Zhou, Anke Wang
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引用次数: 0

摘要

前庭偏头痛(VM)是成人眩晕最常见的病因。VM伴脑干症状并不罕见,但迄今未得到充分认识。常被误诊为脑干梗塞。早期正确诊断有助于避免溶栓、血管内干预、过度辅助检查、恐慌恐惧、反复住院、医疗资源浪费、早期和短期使用类固醇激素、抗氧化剂。家族性或散发性偏瘫性偏头痛(HM)是一种代替单纯脑灌注不足的脑病;发病机制尚未被很好地描述,可能也解释了VM患者的神经症状。偏头痛的基因组鉴定有助于更好地了解家族性HM的分子发病机制。基因突变被认为与大脑皮层扩张性抑制的易感改变有关。中华神经科杂志。2021;11(5):77-86 doi: https://doi.org/10.14740/jnr651
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vestibular Migraine With Brainstem Auras: A Review of Pathogenesis, Clinical Varieties, Abortive and Prophylactic Treatment
Vestibular migraine (VM) is the most common etiology of vertigo in the adults. VM accompanied by brainstem symptoms is not uncommon, but underrecognized so far. It is often misdiagnosed as brainstem infarction. Earlier correct diagnosis could help avoid thrombolysis, intravascular intervention, excessive auxiliary examination, panic and fear, repeated hospitalization, waste of medical resources, early and short-term use of steroid hormone, and antioxidant. Family or sporadic hemiplegic migraine (HM) is a kind of encephalopathy instead of simple hypoperfusion; the pathogenesis, which was not well described, might also account for the neurological symptoms in VM patients. The genomic identification of the migraine could facilitate better understanding on molecular pathogenesis of familial HM. Genetic mutations are believed to be associated with more susceptible alterations of cortical spreading depression in the brain. J Neurol Res. 2021;11(5):77-86 doi: https://doi.org/10.14740/jnr651
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