{"title":"1-烷基-2,5-哌嗪二酮的制备*","authors":"William O. Foye, Douglas H. Kay","doi":"10.1002/jps.3030491106","DOIUrl":null,"url":null,"abstract":"<div><p>General methods for the preparation of 1-alkyl-2,5-piperazinediones were found in the cyclization of N-alkylglycylglycines and the alkylation of the sodium salt of 1-acetyl-2,5-piperazinedione. 1-Methyl-2,5-piperazinedione showed significant antispasmodic activity.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Pages 705-708"},"PeriodicalIF":0.0000,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491106","citationCount":"1","resultStr":"{\"title\":\"Preparation of 1-Alkyl-2,5-piperazinediones*\",\"authors\":\"William O. Foye, Douglas H. Kay\",\"doi\":\"10.1002/jps.3030491106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>General methods for the preparation of 1-alkyl-2,5-piperazinediones were found in the cyclization of N-alkylglycylglycines and the alkylation of the sodium salt of 1-acetyl-2,5-piperazinedione. 1-Methyl-2,5-piperazinedione showed significant antispasmodic activity.</p></div>\",\"PeriodicalId\":100839,\"journal\":{\"name\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"volume\":\"49 11\",\"pages\":\"Pages 705-708\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1960-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/jps.3030491106\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0095955315363605\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315363605","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
General methods for the preparation of 1-alkyl-2,5-piperazinediones were found in the cyclization of N-alkylglycylglycines and the alkylation of the sodium salt of 1-acetyl-2,5-piperazinedione. 1-Methyl-2,5-piperazinedione showed significant antispasmodic activity.
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