用于蛋白质去糖基化的Amadoriase工程酶

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-07-08 DOI:10.18143/JISANH_V3I2_1436

F. Rigoldi, A. D. Vedove, S. Vesentini, E. Parisini, A. Gautieri

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引用次数: 0

摘要

晚期糖基化终产物(AGEs)在人体内的逐渐积累会导致一些有害的后果，包括组织硬化和病理(动脉硬化、肾病和阿尔茨海默病)。目前还没有有效的治疗方法来对抗AGEs的积累，尽管一种很有前途的策略是重糖化酶(faox)，但由于其活性位点被埋没，faox对整个蛋白质不起作用。

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AMADORIASE ENGINEERED ENZYME FOR PROTEIN DEGLYCATION

The progressive accumulation of Advanced Glycation End-product (AGEs) in the human body leads to several deleterious consequences, involving tissues stiffening and pathologies (aterosclerosis, nephropathy, and Alzheimer’s disease). Nowadays there are no effective therapies against AGEs build-up, although a promising strategy is redeglycating enzymes (FAOXs), which are however inactive towards entire proteins due to their buried active site.

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Journal of the International Society of Antioxidants in Nutrition & Health

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