关键时期及产前热应激对成熟豚鼠学习和脑发育的影响

J.G. Lyle , M.J. Edwards , K.M. Jonson
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引用次数: 20

摘要

怀孕的豚鼠连续5天每天暴露在高温下1小时,会导致成熟后代的学习缺陷和脑重量减少,这取决于暴露发生时的胎龄。那些在怀孕三分之一的时候(20-24天)接受治疗的孩子在学习表现上有明显的缺陷,整个和部分大脑的重量都减少了。那些在妊娠期三分之二(40-44天)接受治疗的人,其后代的学习障碍较小,大脑重量的减少也有限。妊娠后期(56-60天)的热疗不会影响后代的学习能力或脑重量。对这些发现的几种可能的解释进行了研究;结论是脑重量减轻是由于在细胞快速增殖的时期有丝分裂被阻断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Critical periods and the effects of prenatal heat stress on the learning and brain growth of mature guinea pigs

The exposure of pregnant guinea pigs to hyperthermia for 1 hr daily on 5 consecutive days produces learning deficits and reduced brain weight in the mature offspring, depending on the gestational age at which exposure took place. The offspring of those treated approximately one-third of the way through pregnancy (20–24 days) show significant deficits in learning performance, and reductions in whole and part brain weights. Those treated about two-thirds of the way through pregnancy (40–44 days) produce offspring which have lesser impairments in learning and a restricted reduction of brain weight. Hyperthermia in late pregnancy, (56–60 days) does not affect the learning or brain weights of the offspring. Several possible explanations for these findings have been examined; and the conclusions are that reduced brain weight is due to a blocking of mitosis at a period of rapid cell proliferation.

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