工作年龄段髋关节和/或膝关节骨性关节炎患者的体育锻炼、自我报告的关节功能和分子生物标志物之间的关系。

Annals of Iowa Pub Date : 2022-03-23 eCollection Date: 2022-01-01 DOI:10.1177/11795441221081063
Elin Östlind, Frida Eek, Kjerstin Stigmar, Anita Sant'Anna, Eva Ekvall Hansson, André Struglics
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引用次数: 0

摘要

目的:以往的研究表明,体力活动(PA)、关节功能和分子生物标志物之间存在关联,但还需要更多的研究。本研究旨在探讨髋关节和/或膝关节骨关节炎(OA)患者的体力活动或自我报告的关节功能与软骨和炎症分子生物标志物之间的关联。具体目标是探索(1)3 个月内自我报告的 PA/关节功能变化与分子生物标志物变化之间的相关性(2)3 个月随访时客观测量的 PA 与分子生物标志物之间的相关性:设计:从群组随机对照试验中招募工作年龄参与者(n = 91)。在基线和 3 个月后收集自我报告的 PA、关节功能和血清样本。用免疫测定法分析血清中炎症标志物 C 反应蛋白(CRP)和软骨标志物丙氨酸-精氨酸-甘氨酸-丝氨酸(ARGS)-骨胶原、软骨低聚基质蛋白(COMP)和 II 型胶原蛋白 C2C 的浓度。从 53 名参与者使用的活动追踪器中收集了 12 周内客观测量的活动量(步数/天)。结果显示,各指标之间存在微弱的负相关:结果:自我报告的活动量变化与 COMP 的变化之间存在微弱的负相关(r s = -0.256,P = .040),但与其他分子生物标志物无关。随访时,自我报告的关节功能变化与分子生物标志物变化之间或平均步数/天与分子生物标志物之间没有相关性(r s ⩽ -0.206,P ⩾.06):总体而言,PA/关节功能与分子生物标志物之间没有关联或仅有微弱关联。未来的研究建议纳入 PA 较低的参与者,延长随访时间,并采用可进行比较的设计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations Between Physical Activity, Self-reported Joint Function, and Molecular Biomarkers in Working Age Individuals With Hip and/or Knee Osteoarthritis.

Objective: Previous research has suggested an association between physical activity (PA), joint function, and molecular biomarkers, but more studies are needed. The aim of this study was to explore the associations between PA or self-reported joint function and molecular biomarkers of cartilage and inflammation in individuals with hip and/or knee osteoarthritis (OA). Specific objectives were to explore the correlations between (1) the change over 3 months in self-reported PA/joint function and the change in molecular biomarkers (2) objectively measured PA and molecular biomarkers measured at 3-month follow-up.

Design: Working age participants (n = 91) were recruited from a cluster randomized controlled trial. Self-reported PA, joint function, and serum samples were collected at baseline and after 3 months. Serum concentrations of the inflammatory marker C-reactive protein (CRP) and the cartilage markers Alanine-Arginine-Glycine-Serine (ARGS)-aggrecan, cartilage oligomeric matrix protein (COMP), and type II collagen C2C were analyzed by immunoassays. Objectively measured PA (steps/day) was collected during 12 weeks from activity trackers used by 53 participants. Associations were analyzed with Spearman's rank correlation.

Results: There was a weak negative correlation between the change in self-reported PA and the change in COMP (r s = -0.256, P = .040) but not for the other molecular biomarkers. There were no correlations between the change in self-reported joint function and the change in molecular biomarkers or between the average steps/day and the molecular biomarkers at follow-up (r s ⩽ -0.206, P ⩾ .06).

Conclusion: In general, no or only weak associations were found between PA/joint function and molecular biomarkers. Future research recommends including participants with lower PA, extend the follow-up, and use a design that allows comparisons.

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