原发性皮肤CD8+ t细胞淋巴瘤

Journal of the Saudi Society of Dermatology & Dermatologic Surgery Pub Date : 2012-01-01 DOI:10.1016/j.jssdds.2011.08.002

Z. Aydi , B. Ben Dhaou , E. Ben Brahim , L. Baili , F. Boussema , S. Ketari , O. Cherif , A. Debbiche , L. Rokbani

{"title":"原发性皮肤CD8+ t细胞淋巴瘤","authors":"Z. Aydi , B. Ben Dhaou , E. Ben Brahim , L. Baili , F. Boussema , S. Ketari , O. Cherif , A. Debbiche , L. Rokbani","doi":"10.1016/j.jssdds.2011.08.002","DOIUrl":null,"url":null,"abstract":"<div><p>Primary cutaneous aggressive CD8<sup>+</sup> T-cell lymphoma is an extremely rare entity with distinct clinicopathological features. We report a case of a 28-year-old man that clinically presented with an ulcerated nodule on his trunk and extremities. Histopathologic sections showed an ulcerated epidermis with a diffuse lymphocytic infiltrate in the superficial dermis with focal epidermotropism. Immunohistochemically, the tumor cells were positive for CD3 and CD8 but negative for CD4, CD20, CD30 and CD56. Granzyme B was positif. He received UVB therapy subsequently associated to interferon with an important regression of the nodules.</p></div>","PeriodicalId":100847,"journal":{"name":"Journal of the Saudi Society of Dermatology & Dermatologic Surgery","volume":"16 1","pages":"Pages 25-28"},"PeriodicalIF":0.0000,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jssdds.2011.08.002","citationCount":"2","resultStr":"{\"title\":\"Primary cutaneous CD8+ T-cell lymphoma\",\"authors\":\"Z. Aydi , B. Ben Dhaou , E. Ben Brahim , L. Baili , F. Boussema , S. Ketari , O. Cherif , A. Debbiche , L. Rokbani\",\"doi\":\"10.1016/j.jssdds.2011.08.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Primary cutaneous aggressive CD8<sup>+</sup> T-cell lymphoma is an extremely rare entity with distinct clinicopathological features. We report a case of a 28-year-old man that clinically presented with an ulcerated nodule on his trunk and extremities. Histopathologic sections showed an ulcerated epidermis with a diffuse lymphocytic infiltrate in the superficial dermis with focal epidermotropism. Immunohistochemically, the tumor cells were positive for CD3 and CD8 but negative for CD4, CD20, CD30 and CD56. Granzyme B was positif. He received UVB therapy subsequently associated to interferon with an important regression of the nodules.</p></div>\",\"PeriodicalId\":100847,\"journal\":{\"name\":\"Journal of the Saudi Society of Dermatology & Dermatologic Surgery\",\"volume\":\"16 1\",\"pages\":\"Pages 25-28\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jssdds.2011.08.002\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Saudi Society of Dermatology & Dermatologic Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210836X11000534\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Saudi Society of Dermatology & Dermatologic Surgery","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210836X11000534","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 2

摘要

原发性皮肤侵袭性CD8+ t细胞淋巴瘤是一种非常罕见的疾病，具有独特的临床病理特征。我们报告一例28岁的男子，临床表现为溃疡结节在他的躯干和四肢。组织病理切片显示表皮溃疡，真皮浅层弥漫性淋巴细胞浸润，伴局灶性嗜表皮。免疫组化结果显示，肿瘤细胞CD3、CD8阳性，CD4、CD20、CD30、CD56阴性。颗粒酶B阳性。他接受了中波紫外线治疗，随后使用干扰素治疗，结节明显消退。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Primary cutaneous CD8+ T-cell lymphoma

Primary cutaneous aggressive CD8⁺ T-cell lymphoma is an extremely rare entity with distinct clinicopathological features. We report a case of a 28-year-old man that clinically presented with an ulcerated nodule on his trunk and extremities. Histopathologic sections showed an ulcerated epidermis with a diffuse lymphocytic infiltrate in the superficial dermis with focal epidermotropism. Immunohistochemically, the tumor cells were positive for CD3 and CD8 but negative for CD4, CD20, CD30 and CD56. Granzyme B was positif. He received UVB therapy subsequently associated to interferon with an important regression of the nodules.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of the Saudi Society of Dermatology & Dermatologic Surgery

CiteScore

2.40

自引率

0.00%

发文量