严重联合免疫缺陷幼儿钙化肉芽肿性肺囊虫肺炎1例报告

Q4 Medicine
F. Zennaro, N. Giurici, N. Maximova
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引用次数: 0

摘要

乙氏肺孢子虫肺炎(PJP)是一种由真菌乙氏肺孢子虫引起的肺炎,是免疫功能低下患者发生严重肺炎的主要原因。PJP典型表现为双侧弥漫性肺浸润。肉芽肿性肺囊虫病是一种罕见的肺囊虫感染,仅发生在3%至5%的患者中。钙化是例外。我们报告了一个9个月大的男孩,患有严重联合免疫缺陷(SCID),在7个月大的时候被诊断为肺肺囊虫感染。在异体造血干细胞移植(HSCT)之前,他接受了常规的全身磁共振成像(MRI)。MRI示肺实质明显改变;因此,计算机断层扫描显示11个钙化肉芽肿结节的存在。我们报告一个独特的钙化肉芽肿性PJP在一个学步儿童影响SCID。考虑到对接受HSCT的患者进行管理时潜在的临床意义,意识到SCID患者中这种罕见但可能出现的表现是很重要的,它进一步增强了HSCT前高级放射学成像的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Calcified Granulomatous Pneumocystis Jirovecii Pneumonia in a Toddler with Severe Combined Immunodeficiency—A Case Report
Pneumocysis jirovecii pneumonia (PJP) is a type of pneumonia originating from the fungus Pneumocystis jiroveci and is a major cause of serious pneumonia in immunocompromised conditions. PJP typically appears as bilateral diffuse pulmonary infiltrates. Granulomatous PJP is an uncommon form of pneumocystis infection, occurring in only 3% to 5% of patients. Calcification is exceptional. We present a 9-month-old boy affected by Severe Combined Immunodeficiency (SCID) that has been diagnosed at the age of 7 months following a lung Pneumocystis jirovecii infection. He underwent a routine total-body magnetic resonance imaging (MRI) prior to an allogeneic hematopoietic stem cell transplantation (HSCT). The MRI showed significant alterations of the pulmonary parenchyma; hence, a computer tomography of the lung was performed showing the presence of 11 calcified granulomatous nodules. We report a unique case of calcified granulomatous PJP in a toddler affected by SCID. Awareness of this rare yet possible presentation in patients with SCID is important given the potential clinical implications when managing a patient undergoing HSCT and it further enhances the importance of advanced radiologic imaging prior to HSCT.
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来源期刊
Cell and Organ Transplantology
Cell and Organ Transplantology Medicine-Transplantation
CiteScore
0.40
自引率
0.00%
发文量
8
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